Impact of previous tobacco use with or without cannabis on first psychotic experiences in patients with first-episode psychosis

Objective: There is high prevalence of cigarette smoking in individuals with first-episode psychosis (FEP) prior to psychosis onset. The purpose of the study was to determine the impact of previous tobacco use with or without cannabis on first psychotic experiences in FEP and the impact of this use...

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Autores: González-Blanco, Leticia, García-Portilla, María Paz|||0000-0003-3643-1622, Gutiérrez, Miguel, Mezquida, Gisela|||0000-0002-6080-2203, Cuesta, Manuel J.|||0000-0003-0250-5718, Urbiola, Elena, Amoretti, Silvia|||0000-0001-6017-2734, Barcones, Fe, González-Pinto, Ana|||0000-0002-2568-5179, Pina-Camacho, Laura|||0000-0003-1960-6443, Corripio, Iluminada|||0000-0003-2562-711X, Vieta, Eduard|||0000-0002-0548-0053, Baeza, Inmaculada|||0000-0003-2611-5781, Toll, Alba|||0000-0003-2399-5250, Sáiz, Pilar A.|||0000-0002-5705-4523, Bobes, Julio|||0000-0003-2187-4033, Bernardo, Miquel|||0000-0001-8748-6717, Bioque, Miquel|||0000-0001-6887-7149, Sagué, M., Alonso-Solís, Anna|||0000-0002-5393-9391, Grasa, Eva|||0000-0003-1100-7489, González-Ortega, Itxaso|||0000-0001-7074-4353, Zorrilla, Iñaki|||0000-0001-6444-8208, Santabárbara, Javier, De-la-Cámara, Concepción|||0000-0003-2284-7862, Aguilar Cortes, Eduardo|||0000-0002-7875-5644, Nacher, Juan|||0000-0001-7599-3957, Bergé Baquero, Daniel|||0000-0003-2544-1016, Mané, Anna|||0000-0003-2127-349X, Montejo, Laura|||0000-0003-4407-9454, Anmella, Gerard|||0000-0002-6798-4054, Castro-Fornieles, Josefina|||0000-0003-0632-2687, de la Serna, Elena|||0000-0002-7869-9881, Contreras, Fernando|||0000-0003-2929-2804, Sáiz-Masvidal, Cristrina, García-Álvarez, Leticia, Bobes-Bascarán, Maria T.|||0000-0002-5279-504X, Zabala Rabadán, Arantzazu, Segarra-Echevarría, Rafael, Sánchez Pastor, Luis|||0000-0002-5360-6351, Rodriguez-Jimenez, Roberto|||0000-0003-2251-7249, Usall, Judith|||0000-0002-1746-7737, Butjosa Molines, Anna|||0000-0001-5317-9508, Sarró, Salvador|||0000-0003-1835-2189, Guerrero-Pedraza, Amalia|||0000-0001-7567-9407, Ibáñez, Ángela, Ribeiro, Maria, Balanzá-Martínez, Vicent|||0000-0001-7772-7396
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:270260
Acceso en línea:https://ddd.uab.cat/record/270260
https://dx.doi.org/urn:doi:10.1016/j.schres.2021.07.017
Access Level:acceso abierto
Palabra clave:Prodromal symptoms
First psychotic symptoms
Substance use
Descripción
Sumario:Objective: There is high prevalence of cigarette smoking in individuals with first-episode psychosis (FEP) prior to psychosis onset. The purpose of the study was to determine the impact of previous tobacco use with or without cannabis on first psychotic experiences in FEP and the impact of this use on age of onset of symptoms, including prodromes. Methods: Retrospective analyses from the naturalistic, longitudinal, multicentre, "Phenotype-Genotype and Environmental Interaction. Application of a Predictive Model in First Psychotic Episodes (PEPs)" Study. The authors analysed sociodemographic/clinical data of 284 FEP patients and 231 matched healthy controls, and evaluated first psychotic experiences of patients using the Symptom Onset in Schizophrenia Inventory. Results: FEP patients had significantly higher prevalence of tobacco, cannabis, and cocaine use than controls. The FEP group with tobacco use only prior to onset (N = 56) had more sleep disturbances (42.9% vs 18.8%, P = 0.003) and lower prevalence of negative symptoms, specifically social withdrawal (33.9% vs 58%, P = 0.007) than FEP with no substance use (N = 70), as well as lower prevalence of ideas of reference (80.4% vs 92.4%, P = 0.015), perceptual abnormalities (46.4% vs 67.4%, P = 0.006), hallucinations (55.4% vs 71.5%, P = 0.029), and disorganised thinking (41.1% vs 61.1%, P = 0.010) than FEP group with previous tobacco and cannabis use (N = 144). FEP patients with cannabis and tobacco use had lower age at first prodromal or psychotic symptom (mean = 23.73 years [SD = 5.09]) versus those with tobacco use only (mean = 26.21 [SD = 4.80]) (P = 0.011). Conclusions: The use of tobacco alone was not related to earlier age of onset of a first psychotic experience, but the clinical profile of FEP patients is different depending on previous tobacco use with or without cannabis.

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