Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients

To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosi...

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Autores: Baeza, Inmaculada|||0000-0003-2611-5781, de la Serna, Elena|||0000-0002-7869-9881, Mezquida, Gisela|||0000-0002-6080-2203, Cuesta, Manuel J.|||0000-0003-0250-5718, Vieta, Eduard|||0000-0002-0548-0053, Amoretti, Silvia|||0000-0001-6017-2734, Lobo, Antonio|||0000-0002-9098-655X, González-Pinto, Ana|||0000-0002-2568-5179, Díaz-Caneja, Covadonga M.|||0000-0001-8538-3175, Corripio, Iluminada|||0000-0003-2562-711X, Valli, Isabel|||0000-0003-3052-7383, Puig, Olga, Mané, Anna|||0000-0003-2127-349X, Bioque, Miquel|||0000-0001-6887-7149, Ayora, Miriam, Bernardo, Miquel|||0000-0001-8748-6717, Castro-Fornieles, Josefina|||0000-0003-0632-2687, Garcia Rizo, Clemente|||0000-0002-4855-1608, González-Díaz, Jairo|||0000-0003-1238-8447, Grasa, Eva|||0000-0003-1100-7489, Roldan-Bejarano, Alexandra|||0000-0001-9905-3943, Casanovas, Francesc|||0000-0003-0557-8381, Toll, Alba|||0000-0003-2399-5250, Verdolini, Norma|||0000-0001-9488-2881, Sagué-Vilabella, Maria, Sugranyes, Gisela|||0000-0002-2545-7862, Ilzarbe, Daniel|||0000-0001-7534-0331, Contreras, Fernando|||0000-0003-2929-2804
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:291409
Acceso en línea:https://ddd.uab.cat/record/291409
https://dx.doi.org/urn:doi:10.1007/s00787-023-02196-7
Access Level:acceso abierto
Palabra clave:Adult onset
Children and adolescents
Prodrome
Prodromal symptoms
Schizophrenia, bipolar disorder, early onset
Descripción
Sumario:To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7-35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33-177] vs. 58 [21-140] days; Z = - 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31-155] vs. 30 [7-66] days; Z = - 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors.

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