Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances

Di(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of tox...

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Autores: Santiago Alvarez, Carlos, Sotomayor Anduiza, María Nuria, Lete Expósito, María Esther
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/45827
Acceso en línea:http://hdl.handle.net/10810/45827
Access Level:acceso abierto
Palabra clave:C-H activation
acylation
palladium
arenes
heteroarenes
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spelling Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent AdvancesSantiago Alvarez, CarlosSotomayor Anduiza, María NuriaLete Expósito, María EstherC-H activationacylationpalladiumarenesheteroarenesDi(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of toxic metal waste. Different directing groups and acyl sources are being studied for this purpose, although further development is required to face mainly selectivity problems in order to be applied in the synthesis of more complex molecules. Selected recent developments and applications are covered in this review.This work is supported by Ministerio de Economía y Competitividad (CTQ2016-74881-P), Ministerio de Ciencia e Innovación (PID2019-104148GB-I00) and Gobierno Vasco (IT1045-16).MDPI2020202020202020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/45827reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoInglésinfo:eu-repo/grantAgreement/MINECO/CTQ2016-74881-P/info:eu-repo/grantAgreement/MCIU/PID2019-104148GB-I00/https://www.mdpi.com/1420-3049/25/14/3247info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/es/© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).oai:addi.ehu.eus:10810/458272026-06-18T09:23:17Z
dc.title.none.fl_str_mv Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
title Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
spellingShingle Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
Santiago Alvarez, Carlos
C-H activation
acylation
palladium
arenes
heteroarenes
title_short Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
title_full Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
title_fullStr Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
title_full_unstemmed Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
title_sort Pd(II)-Catalyzed C-H Acylation of (Hetero)arenes. Recent Advances
dc.creator.none.fl_str_mv Santiago Alvarez, Carlos
Sotomayor Anduiza, María Nuria
Lete Expósito, María Esther
author Santiago Alvarez, Carlos
author_facet Santiago Alvarez, Carlos
Sotomayor Anduiza, María Nuria
Lete Expósito, María Esther
author_role author
author2 Sotomayor Anduiza, María Nuria
Lete Expósito, María Esther
author2_role author
author
dc.subject.none.fl_str_mv C-H activation
acylation
palladium
arenes
heteroarenes
topic C-H activation
acylation
palladium
arenes
heteroarenes
description Di(hetero)aryl ketones are important motifs present in natural products, pharmaceuticals or agrochemicals. In recent years, Pd(II)-catalyzed acylation of (hetero)arenes in the presence of an oxidant has emerged as a catalytic alternative to classical acylation methods, reducing the production of toxic metal waste. Different directing groups and acyl sources are being studied for this purpose, although further development is required to face mainly selectivity problems in order to be applied in the synthesis of more complex molecules. Selected recent developments and applications are covered in this review.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/45827
url http://hdl.handle.net/10810/45827
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/MINECO/CTQ2016-74881-P/
info:eu-repo/grantAgreement/MCIU/PID2019-104148GB-I00/
https://www.mdpi.com/1420-3049/25/14/3247
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/3.0/es/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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