Methane Catalytic Amidation via a Plausible Copper-Nitrene Intermediate
The catalytic conversion of CH4 into CH3X compounds has been reported in a few cases, usually involving dehydrogenative processes in which the H atom is lost. Aiming at expanding this limited set of transformations, we have investigated the methane amidation reaction through metal-catalyzed nitrene...
| Authors: | , , , , , , |
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| Format: | article |
| Publication Date: | 2026 |
| Country: | España |
| Institution: | Universidad de Huelva (UHU) |
| Repository: | Arias Montano. Repositorio Institucional de la Universidad de Huelva |
| Language: | English |
| OAI Identifier: | oai:dnet:ariasmontano::49cdb77e5e3c5d37a634bdc482d2146c |
| Online Access: | https://hdl.handle.net/10272/28207 |
| Access Level: | Open access |
| Keyword: | Catalysts Copper Functionalization Hydrocarbons Organic reactions 2306.11 Compuestos Organometálicos 2210.01 Catálisis |
| Summary: | The catalytic conversion of CH4 into CH3X compounds has been reported in a few cases, usually involving dehydrogenative processes in which the H atom is lost. Aiming at expanding this limited set of transformations, we have investigated the methane amidation reaction through metal-catalyzed nitrene transfer reactions, a transformation that remains unreported to date for the lightest hydrocarbon. Herein, we describe the use of copper-based catalysts for the direct, nondehydrogenative amidation reaction of methane via a metal-mediated formal nitrene insertion into the C−H bond, a reaction that is also extended to the series of gaseous alkanes. Mechanistic studies, supported by DFT calculations, a microkinetic model, and experimental evidence have led to the proposal of a metallonitrene intermediate responsible for this C−H amidation process via sequential hydrogen abstraction and rebound steps. |
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