Chimeras for the twenty-first century

Recent advances in stem cell biology and molecular engineering have improved and simplified the methodology employed to create experimental chimeras, highlighting their value in basic research and broadening the spectrum of potential applications. Experimental chimeras have been used for decades dur...

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Autores: Morata Tarifa, Cynthia, López Navas, Luis, Azkona Mendoza, Garikoitz, Sánchez Pernaute, Rosario
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad del País Vasco
Repositorio:Addi. Archivo Digital para la Docencia y la Investigación
OAI Identifier:oai:addi.ehu.eus:10810/66515
Acceso en línea:http://hdl.handle.net/10810/66515
Access Level:acceso abierto
Palabra clave:blastocyst complementation
chimera
embryonic stem cells
ethics
interspecific
organogenesis
organoids
pluripotent stem cells
tissue engineering
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spelling Chimeras for the twenty-first centuryMorata Tarifa, CynthiaLópez Navas, LuisAzkona Mendoza, GarikoitzSánchez Pernaute, Rosarioblastocyst complementationchimeraembryonic stem cellsethicsinterspecificorganogenesisorganoidspluripotent stem cellstissue engineeringRecent advances in stem cell biology and molecular engineering have improved and simplified the methodology employed to create experimental chimeras, highlighting their value in basic research and broadening the spectrum of potential applications. Experimental chimeras have been used for decades during the generation of murine genetic models, this being especially relevant in developmental and regeneration studies. Indeed, their value for the research and modeling of human diseases was recognized by the 2007 Nobel Prize to Mario Capecchi, Martin Evans, and Oliver Smithies. More recently, their potential application in regenerative medicine has generated a lot of interest, particularly the enticing possibility to generate human organs for transplantation in livestock animals. In this review, we provide an update on interspecific chimeric organogenesis, its possibilities, current limitations, alternatives, and ethical issues.Taylor & Francis202420242020info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10810/66515reponame:Addi. Archivo Digital para la Docencia y la Investigacióninstname:Universidad del País VascoIngléshttps://www.tandfonline.com/doi/full/10.1080/07388551.2019.1679084info:eu-repo/semantics/openAccess(c)2020 Taylor & Francisoai:addi.ehu.eus:10810/665152026-06-18T09:23:17Z
dc.title.none.fl_str_mv Chimeras for the twenty-first century
title Chimeras for the twenty-first century
spellingShingle Chimeras for the twenty-first century
Morata Tarifa, Cynthia
blastocyst complementation
chimera
embryonic stem cells
ethics
interspecific
organogenesis
organoids
pluripotent stem cells
tissue engineering
title_short Chimeras for the twenty-first century
title_full Chimeras for the twenty-first century
title_fullStr Chimeras for the twenty-first century
title_full_unstemmed Chimeras for the twenty-first century
title_sort Chimeras for the twenty-first century
dc.creator.none.fl_str_mv Morata Tarifa, Cynthia
López Navas, Luis
Azkona Mendoza, Garikoitz
Sánchez Pernaute, Rosario
author Morata Tarifa, Cynthia
author_facet Morata Tarifa, Cynthia
López Navas, Luis
Azkona Mendoza, Garikoitz
Sánchez Pernaute, Rosario
author_role author
author2 López Navas, Luis
Azkona Mendoza, Garikoitz
Sánchez Pernaute, Rosario
author2_role author
author
author
dc.subject.none.fl_str_mv blastocyst complementation
chimera
embryonic stem cells
ethics
interspecific
organogenesis
organoids
pluripotent stem cells
tissue engineering
topic blastocyst complementation
chimera
embryonic stem cells
ethics
interspecific
organogenesis
organoids
pluripotent stem cells
tissue engineering
description Recent advances in stem cell biology and molecular engineering have improved and simplified the methodology employed to create experimental chimeras, highlighting their value in basic research and broadening the spectrum of potential applications. Experimental chimeras have been used for decades during the generation of murine genetic models, this being especially relevant in developmental and regeneration studies. Indeed, their value for the research and modeling of human diseases was recognized by the 2007 Nobel Prize to Mario Capecchi, Martin Evans, and Oliver Smithies. More recently, their potential application in regenerative medicine has generated a lot of interest, particularly the enticing possibility to generate human organs for transplantation in livestock animals. In this review, we provide an update on interspecific chimeric organogenesis, its possibilities, current limitations, alternatives, and ethical issues.
publishDate 2020
dc.date.none.fl_str_mv 2020
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10810/66515
url http://hdl.handle.net/10810/66515
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://www.tandfonline.com/doi/full/10.1080/07388551.2019.1679084
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
(c)2020 Taylor & Francis
eu_rights_str_mv openAccess
rights_invalid_str_mv (c)2020 Taylor & Francis
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:Addi. Archivo Digital para la Docencia y la Investigación
instname:Universidad del País Vasco
instname_str Universidad del País Vasco
reponame_str Addi. Archivo Digital para la Docencia y la Investigación
collection Addi. Archivo Digital para la Docencia y la Investigación
repository.name.fl_str_mv
repository.mail.fl_str_mv
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