Advances in enzymatic oxyfunctionalization of aliphatic compounds

19 páginas.- 8 figuras.- 5 tablas.- 174 referencias

Detalles Bibliográficos
Autores: Aranda, Carmen, Carro, Juan, González-Benjumea, Alejandro, Babot, Esteban Daniel, Olmedo, Andrés, Linde, Dolores, Martínez, Ángel T., Gutiérrez Suárez, Ana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/236621
Acceso en línea:http://hdl.handle.net/10261/236621
Access Level:acceso abierto
Palabra clave:Alkanes
Biocatalysis
Epoxidation
Fatty acids
Hydroxylation
Oxyfunctionalization
Peroxygenases
Terpenoids
UPO
P450
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spelling Advances in enzymatic oxyfunctionalization of aliphatic compoundsAranda, CarmenCarro, JuanGonzález-Benjumea, AlejandroBabot, Esteban DanielOlmedo, AndrésLinde, DoloresMartínez, Ángel T.Gutiérrez Suárez, AnaAlkanesBiocatalysisEpoxidationFatty acidsHydroxylationOxyfunctionalizationPeroxygenasesTerpenoidsUPOP45019 páginas.- 8 figuras.- 5 tablas.- 174 referenciasSelective oxyfunctionalizations of aliphatic compounds are difficult chemical reactions, where enzymes can play an important role due to their stereo- and regio-selectivity and operation under mild reaction conditions. P450 monooxygenases are well-known biocatalysts that mediate oxyfunctionalization reactions in different living organisms (from bacteria to humans). Unspecific peroxygenases (UPOs), discovered in fungi, have arisen as “dream biocatalysts” of great biotechnological interest because they catalyze the oxyfunctionalization of aliphatic and aromatic compounds, avoiding the necessity of expensive cofactors and regeneration systems, and only depending on H2O2 for their catalysis. Here, we summarize recent advances in aliphatic oxyfunctionalization reactions by UPOs, as well as the molecular determinants of the enzyme structures responsible for their activities, emphasizing the differences found between well-known P450s and the novel fungal peroxygenases. © 2021 The AuthorsThis work has received funding from the Bio Based Industries Joint Undertaking under the European Union's Horizon 2020 research and innovation programme under Grant Agreement No 792063 (Development and pilot production of sustainable binder systems for wood based panels, https://susbind.eu), and from the Spanish Ministry of Industry, Economy and Competitiveness project BIO2017-86559-R, cofinanced by FEDER funds, and the Consejo Superior de Investigaciones Científicas projects PIE-201620E081 and PIE-202040E185Peer reviewedElsevierEuropean CommissionMinisterio de Economía, Industria y Competitividad (España)Consejo Superior de Investigaciones Científicas (España)Bio-Based IndustriesAranda, Carmen [0000-0001-8213-1132]Carro, Juan [0000-0002-7556-9782]González-Benjumea, Alejandro [0000-0003-2857-9491]Babot, Esteban Daniel [0000-0001-5539-1721]Olmedo, Andrés [0000-0002-7039-1436]Linde, Dolores [0000-0002-0359-0566]Martínez, Ángel T. [0000-0002-1584-2863]Gutiérrez Suárez, Ana [0000-0002-8823-9029]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202120212021info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/236621reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/792063info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BIO2017-86559-Rinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PIE-201620E081info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PIE-202040E18http://dx.doi.org/10.1016/j.biotechadv.2021.107703Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2366212026-05-22T06:33:51Z
dc.title.none.fl_str_mv Advances in enzymatic oxyfunctionalization of aliphatic compounds
title Advances in enzymatic oxyfunctionalization of aliphatic compounds
spellingShingle Advances in enzymatic oxyfunctionalization of aliphatic compounds
Aranda, Carmen
Alkanes
Biocatalysis
Epoxidation
Fatty acids
Hydroxylation
Oxyfunctionalization
Peroxygenases
Terpenoids
UPO
P450
title_short Advances in enzymatic oxyfunctionalization of aliphatic compounds
title_full Advances in enzymatic oxyfunctionalization of aliphatic compounds
title_fullStr Advances in enzymatic oxyfunctionalization of aliphatic compounds
title_full_unstemmed Advances in enzymatic oxyfunctionalization of aliphatic compounds
title_sort Advances in enzymatic oxyfunctionalization of aliphatic compounds
dc.creator.none.fl_str_mv Aranda, Carmen
Carro, Juan
González-Benjumea, Alejandro
Babot, Esteban Daniel
Olmedo, Andrés
Linde, Dolores
Martínez, Ángel T.
Gutiérrez Suárez, Ana
author Aranda, Carmen
author_facet Aranda, Carmen
Carro, Juan
González-Benjumea, Alejandro
Babot, Esteban Daniel
Olmedo, Andrés
Linde, Dolores
Martínez, Ángel T.
Gutiérrez Suárez, Ana
author_role author
author2 Carro, Juan
González-Benjumea, Alejandro
Babot, Esteban Daniel
Olmedo, Andrés
Linde, Dolores
Martínez, Ángel T.
Gutiérrez Suárez, Ana
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv European Commission
Ministerio de Economía, Industria y Competitividad (España)
Consejo Superior de Investigaciones Científicas (España)
Bio-Based Industries
Aranda, Carmen [0000-0001-8213-1132]
Carro, Juan [0000-0002-7556-9782]
González-Benjumea, Alejandro [0000-0003-2857-9491]
Babot, Esteban Daniel [0000-0001-5539-1721]
Olmedo, Andrés [0000-0002-7039-1436]
Linde, Dolores [0000-0002-0359-0566]
Martínez, Ángel T. [0000-0002-1584-2863]
Gutiérrez Suárez, Ana [0000-0002-8823-9029]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Alkanes
Biocatalysis
Epoxidation
Fatty acids
Hydroxylation
Oxyfunctionalization
Peroxygenases
Terpenoids
UPO
P450
topic Alkanes
Biocatalysis
Epoxidation
Fatty acids
Hydroxylation
Oxyfunctionalization
Peroxygenases
Terpenoids
UPO
P450
description 19 páginas.- 8 figuras.- 5 tablas.- 174 referencias
publishDate 2021
dc.date.none.fl_str_mv 2021
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/236621
url http://hdl.handle.net/10261/236621
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/792063
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/BIO2017-86559-R
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/PIE-201620E081
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PIE-202040E18
http://dx.doi.org/10.1016/j.biotechadv.2021.107703
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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