Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds

Background/Objectives: Understanding the genetic architecture of autochthonous European cattle breeds is important for developing effective conservation strategies and sustainable breeding programs. Spanish beef cattle, which trace their origins to ancient migrations from the Near East with later ad...

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Autores: Hervás-Rivero, Carlos|||0009-0004-9561-9048, Mejuto-Vázquez, N., López Carbonell, David|||0000-0003-0964-9212, Altarriba, Juan|||0000-0002-3042-2250, Diaz, Clara|||0000-0001-8483-9062, Molina, Antonio|||0000-0002-9566-6600, Rodríguez-Bermúdez, Ruth|||0000-0002-3372-6575, Piedrafita Arilla, Jesús|||0000-0003-1127-6988, Baro, Jesus A.|||0000-0002-3255-2585, Varona, Luis|||0000-0001-6256-5478
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:308217
Acceso en línea:https://ddd.uab.cat/record/308217
https://dx.doi.org/urn:doi:10.3390/genes15111477
Access Level:acceso abierto
Palabra clave:Autochthonous cattle
Runs of homozygosity (ROH)
ROH islands
Selection signatures
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spelling Runs of Homozygosity Islands in Autochthonous Spanish Cattle BreedsHervás-Rivero, Carlos|||0009-0004-9561-9048Mejuto-Vázquez, N.López Carbonell, David|||0000-0003-0964-9212Altarriba, Juan|||0000-0002-3042-2250Diaz, Clara|||0000-0001-8483-9062Molina, Antonio|||0000-0002-9566-6600Rodríguez-Bermúdez, Ruth|||0000-0002-3372-6575Piedrafita Arilla, Jesús|||0000-0003-1127-6988Baro, Jesus A.|||0000-0002-3255-2585Varona, Luis|||0000-0001-6256-5478Autochthonous cattleRuns of homozygosity (ROH)ROH islandsSelection signaturesBackground/Objectives: Understanding the genetic architecture of autochthonous European cattle breeds is important for developing effective conservation strategies and sustainable breeding programs. Spanish beef cattle, which trace their origins to ancient migrations from the Near East with later admixture from African populations, exhibit a rich genetic diversity shaped by environmental adaptation and selective breeding. Runs of Homozygosity (ROH) are extended stretches of identical genetic material inherited from both parents. They serve as indicators of inbreeding and selection signatures within populations. ROH islands, or regions of the genome where ROH segments are highly concentrated across individuals within a breed, indicate genomic regions under selective pressure. Methods: This study explores the distribution of ROH islands across seven Spanish beef cattle breeds (Asturiana de los Valles, Avileña-Negra Ibérica, Bruna dels Pirineus, Morucha, Retinta, Pirenaica, and Rubia Gallega). By analyzing high-density SNP data, we characterized ROH patterns and identified genomic regions with high levels of homozygosity, which may indicate selection pressures or common ancestry. Results: Our findings revealed breed-specific ROH patterns as well as shared ROH islands, underscoring genetic relationships and differentiation among the breeds. Notably, Morucha displayed the highest number of ROH, while Asturiana de los Valles had the fewest. F values, which indicate genomic inbreeding, varied among the breeds, with Morucha and Retinta being associated with higher values. We identified 57 ROH islands, with shared regions among populations that suggest common ancestral selection pressures. Key genes within these regions, like MSTN, are associated with muscle growth, body weight, and fertility. Conclusions: This study offers valuable insights for breeding strategies and conservation efforts, highlighting the genetic diversity and historical background of Spanish cattle breeds. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/308217https://dx.doi.org/urn:doi:10.3390/genes15111477reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 AGL2010-15903open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3082172026-06-06T12:50:31Z
dc.title.none.fl_str_mv Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
title Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
spellingShingle Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
Hervás-Rivero, Carlos|||0009-0004-9561-9048
Autochthonous cattle
Runs of homozygosity (ROH)
ROH islands
Selection signatures
title_short Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
title_full Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
title_fullStr Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
title_full_unstemmed Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
title_sort Runs of Homozygosity Islands in Autochthonous Spanish Cattle Breeds
dc.creator.none.fl_str_mv Hervás-Rivero, Carlos|||0009-0004-9561-9048
Mejuto-Vázquez, N.
López Carbonell, David|||0000-0003-0964-9212
Altarriba, Juan|||0000-0002-3042-2250
Diaz, Clara|||0000-0001-8483-9062
Molina, Antonio|||0000-0002-9566-6600
Rodríguez-Bermúdez, Ruth|||0000-0002-3372-6575
Piedrafita Arilla, Jesús|||0000-0003-1127-6988
Baro, Jesus A.|||0000-0002-3255-2585
Varona, Luis|||0000-0001-6256-5478
author Hervás-Rivero, Carlos|||0009-0004-9561-9048
author_facet Hervás-Rivero, Carlos|||0009-0004-9561-9048
Mejuto-Vázquez, N.
López Carbonell, David|||0000-0003-0964-9212
Altarriba, Juan|||0000-0002-3042-2250
Diaz, Clara|||0000-0001-8483-9062
Molina, Antonio|||0000-0002-9566-6600
Rodríguez-Bermúdez, Ruth|||0000-0002-3372-6575
Piedrafita Arilla, Jesús|||0000-0003-1127-6988
Baro, Jesus A.|||0000-0002-3255-2585
Varona, Luis|||0000-0001-6256-5478
author_role author
author2 Mejuto-Vázquez, N.
López Carbonell, David|||0000-0003-0964-9212
Altarriba, Juan|||0000-0002-3042-2250
Diaz, Clara|||0000-0001-8483-9062
Molina, Antonio|||0000-0002-9566-6600
Rodríguez-Bermúdez, Ruth|||0000-0002-3372-6575
Piedrafita Arilla, Jesús|||0000-0003-1127-6988
Baro, Jesus A.|||0000-0002-3255-2585
Varona, Luis|||0000-0001-6256-5478
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Autochthonous cattle
Runs of homozygosity (ROH)
ROH islands
Selection signatures
topic Autochthonous cattle
Runs of homozygosity (ROH)
ROH islands
Selection signatures
description Background/Objectives: Understanding the genetic architecture of autochthonous European cattle breeds is important for developing effective conservation strategies and sustainable breeding programs. Spanish beef cattle, which trace their origins to ancient migrations from the Near East with later admixture from African populations, exhibit a rich genetic diversity shaped by environmental adaptation and selective breeding. Runs of Homozygosity (ROH) are extended stretches of identical genetic material inherited from both parents. They serve as indicators of inbreeding and selection signatures within populations. ROH islands, or regions of the genome where ROH segments are highly concentrated across individuals within a breed, indicate genomic regions under selective pressure. Methods: This study explores the distribution of ROH islands across seven Spanish beef cattle breeds (Asturiana de los Valles, Avileña-Negra Ibérica, Bruna dels Pirineus, Morucha, Retinta, Pirenaica, and Rubia Gallega). By analyzing high-density SNP data, we characterized ROH patterns and identified genomic regions with high levels of homozygosity, which may indicate selection pressures or common ancestry. Results: Our findings revealed breed-specific ROH patterns as well as shared ROH islands, underscoring genetic relationships and differentiation among the breeds. Notably, Morucha displayed the highest number of ROH, while Asturiana de los Valles had the fewest. F values, which indicate genomic inbreeding, varied among the breeds, with Morucha and Retinta being associated with higher values. We identified 57 ROH islands, with shared regions among populations that suggest common ancestral selection pressures. Key genes within these regions, like MSTN, are associated with muscle growth, body weight, and fertility. Conclusions: This study offers valuable insights for breeding strategies and conservation efforts, highlighting the genetic diversity and historical background of Spanish cattle breeds.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/308217
https://dx.doi.org/urn:doi:10.3390/genes15111477
url https://ddd.uab.cat/record/308217
https://dx.doi.org/urn:doi:10.3390/genes15111477
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 AGL2010-15903
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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