Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC

Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical out come following myocardial infarction but is inevitably associated with ischemia-reperfusion injury(IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ische...

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Detalhes bibliográficos
Autores: Martin-Puig, Silvia, Tello, Daniel, Aragonés López, Julián
Tipo de documento: artigo
Data de publicação:2015
País:España
Recursos:Universidad Autónoma de Madrid
Repositório:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglês
OAI Identifier:oai:repositorio.uam.es:10486/672234
Acesso em linha:http://hdl.handle.net/10486/672234
https://dx.doi.org/10.3389/fphys.2015.00137
Access Level:Acceso aberto
Palavra-chave:Heart
Ischemic preconditioning
PHD oxygen sensors
Hypoxia-inducible factors
Remote ischemic preconditioning
Medicina
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spelling Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPCMartin-Puig, SilviaTello, DanielAragonés López, JuliánHeartIschemic preconditioningPHD oxygen sensorsHypoxia-inducible factorsRemote ischemic preconditioningMedicinaReperfusion of ischemic cardiac tissue is the standard treatment for improving clinical out come following myocardial infarction but is inevitably associated with ischemia-reperfusion injury(IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ischemia-reperfusion prior to the ischemic insult, a phenomenon that has been termed ischemic preconditioning (IPC).Similarly, remote IPC (RIPC) is defined as transient episodes of ischemia at a distant site before a subsequent prolonged injury of the target organ. In this setting, adaptive responses to hypoxia/ischemia in peripheral issues include the release of soluble factors that have the potential to protect cardiomyocytes remotely. Oxygen fluctuations is a hallmark of insufficient tissue perfusion and ischemic episodes. Emerging evidence indicates that prolyl hydroxylase oxygen sensors (PHDs) and hypoxia-inducible transcription factors (HIFs) are critical regulators of IPC and RIPC. In this review, we discuss recent findings concerning the role of the PHD-HIF axis in IPC and RIPC-mediated cardio protection and examine molecular pathways and cell types that might be involved. We also appraise the therapeutic value of targeting the PHD-HIF axis to enhance cardiac tolerance against IRI.This work has been supported by grants from Ministerio de Economia y Competitividad (SAF2 013-46058-R) and (SAF2011- 29830), Comunidad de Madrid/Fondo Social Europeo (S2010/ BMD-2542), Miguel Servet Program (CP09/00100), Red de Cardiovascular (RD12/0042/0065) and JCI-2012-11943Frontiers MediaDepartamento de MedicinaFacultad de Medicina20152015-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/672234https://dx.doi.org/10.3389/fphys.2015.00137reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6722342026-06-23T12:46:27Z
dc.title.none.fl_str_mv Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
title Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
spellingShingle Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
Martin-Puig, Silvia
Heart
Ischemic preconditioning
PHD oxygen sensors
Hypoxia-inducible factors
Remote ischemic preconditioning
Medicina
title_short Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
title_full Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
title_fullStr Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
title_full_unstemmed Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
title_sort Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
dc.creator.none.fl_str_mv Martin-Puig, Silvia
Tello, Daniel
Aragonés López, Julián
author Martin-Puig, Silvia
author_facet Martin-Puig, Silvia
Tello, Daniel
Aragonés López, Julián
author_role author
author2 Tello, Daniel
Aragonés López, Julián
author2_role author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
dc.subject.none.fl_str_mv Heart
Ischemic preconditioning
PHD oxygen sensors
Hypoxia-inducible factors
Remote ischemic preconditioning
Medicina
topic Heart
Ischemic preconditioning
PHD oxygen sensors
Hypoxia-inducible factors
Remote ischemic preconditioning
Medicina
description Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical out come following myocardial infarction but is inevitably associated with ischemia-reperfusion injury(IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ischemia-reperfusion prior to the ischemic insult, a phenomenon that has been termed ischemic preconditioning (IPC).Similarly, remote IPC (RIPC) is defined as transient episodes of ischemia at a distant site before a subsequent prolonged injury of the target organ. In this setting, adaptive responses to hypoxia/ischemia in peripheral issues include the release of soluble factors that have the potential to protect cardiomyocytes remotely. Oxygen fluctuations is a hallmark of insufficient tissue perfusion and ischemic episodes. Emerging evidence indicates that prolyl hydroxylase oxygen sensors (PHDs) and hypoxia-inducible transcription factors (HIFs) are critical regulators of IPC and RIPC. In this review, we discuss recent findings concerning the role of the PHD-HIF axis in IPC and RIPC-mediated cardio protection and examine molecular pathways and cell types that might be involved. We also appraise the therapeutic value of targeting the PHD-HIF axis to enhance cardiac tolerance against IRI.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/672234
https://dx.doi.org/10.3389/fphys.2015.00137
url http://hdl.handle.net/10486/672234
https://dx.doi.org/10.3389/fphys.2015.00137
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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