Novel perspectives on the PHD-HIF oxygen sensing pathway in cardioprotection mediated by IPC and RIPC
Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical out come following myocardial infarction but is inevitably associated with ischemia-reperfusion injury(IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ische...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/672234 |
| Acceso en línea: | http://hdl.handle.net/10486/672234 https://dx.doi.org/10.3389/fphys.2015.00137 |
| Access Level: | acceso abierto |
| Palabra clave: | Heart Ischemic preconditioning PHD oxygen sensors Hypoxia-inducible factors Remote ischemic preconditioning Medicina |
| Sumario: | Reperfusion of ischemic cardiac tissue is the standard treatment for improving clinical out come following myocardial infarction but is inevitably associated with ischemia-reperfusion injury(IRI). Ischemic myocardial injury can be alleviated by exposing the heart to brief episodes of sublethal ischemia-reperfusion prior to the ischemic insult, a phenomenon that has been termed ischemic preconditioning (IPC).Similarly, remote IPC (RIPC) is defined as transient episodes of ischemia at a distant site before a subsequent prolonged injury of the target organ. In this setting, adaptive responses to hypoxia/ischemia in peripheral issues include the release of soluble factors that have the potential to protect cardiomyocytes remotely. Oxygen fluctuations is a hallmark of insufficient tissue perfusion and ischemic episodes. Emerging evidence indicates that prolyl hydroxylase oxygen sensors (PHDs) and hypoxia-inducible transcription factors (HIFs) are critical regulators of IPC and RIPC. In this review, we discuss recent findings concerning the role of the PHD-HIF axis in IPC and RIPC-mediated cardio protection and examine molecular pathways and cell types that might be involved. We also appraise the therapeutic value of targeting the PHD-HIF axis to enhance cardiac tolerance against IRI. |
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