Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis

ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS). Methods276 CIS patients with a minimum follow-up of...

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Autores: Vicente, CA, Lacruz, L, Gascon, F, Carratala, S, Quintanilla-Bordas, C, Sanz, MT, Carcelen-Gadea, M, Mallada, J, Carreres, J, Torres, LG, Dominguez, JA, Canizares, E, Gil-Perotin, S, Cubas, L, Rubio, RG, Castillo-Villalba, J, Perez-Miralles, FC, Casanova, B
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p14670
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/14670
Access Level:acceso abierto
Palabra clave:OCMB
oligoclonal M bands
spinal cord
secondary progressive MS
multiple sclerosis
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spelling Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosisVicente, CALacruz, LGascon, FCarratala, SQuintanilla-Bordas, CSanz, MTCarcelen-Gadea, MMallada, JCarreres, JTorres, LGDominguez, JACanizares, EGil-Perotin, SCubas, LRubio, RGCastillo-Villalba, JPerez-Miralles, FCCasanova, BOCMBoligoclonal M bandsspinal cordsecondary progressive MSmultiple sclerosisObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS). Methods276 CIS patients with a minimum follow-up of 10 years were studied. Baseline presence of oligoclonal IgG and IgM bands (OCGB and OCMB respectively); number of brain T2 lesions (B-T2L), brain gadolinium enhancement lesions (brain-GEL), cervical spinal cord T2 lesions (cSC-T2L); and fulfillment of 2017 McDonald criteria among other variables were collected. Results14 patients ended up with a non-MS condition. 138/276 CIS patients fulfilled 2017 McDonald criteria. Mean age was 32.4 years, 185 female. 227 received treatment, 95 as CIS. After a mean follow-up of 12 years, 36 patients developed SPMS. Conversion to SPMS was associated with OCGB (p = 0.02), OCMB (p = 0.0001); >= 9 B-T2L (p = 0.03), brain-GEL (p = 0.03), and cSC-T2L (p = 0.03). However, after adjusting for sex, age, BT2L, brain-GEL, SC-T2, and OCMB status, only OCMB (HR 4.4, 1.9-10.6) and cSC-T2L (HR 2.2, 1.0-6.2) suggested an independent association with risk of conversion to SPMS. Patients with both risk factors had a HR of 6.12 (2.8-12.9). DiscussionOCMB and SC-T2 lesions are potential independent predictors of conversion to SPMS.FRONTIERS MEDIA SA2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/14670Frontiers in NeurologyISSN: 16642295reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p146702026-06-11T12:45:17Z
dc.title.none.fl_str_mv Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
title Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
spellingShingle Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
Vicente, CA
OCMB
oligoclonal M bands
spinal cord
secondary progressive MS
multiple sclerosis
title_short Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
title_full Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
title_fullStr Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
title_full_unstemmed Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
title_sort Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis
dc.creator.none.fl_str_mv Vicente, CA
Lacruz, L
Gascon, F
Carratala, S
Quintanilla-Bordas, C
Sanz, MT
Carcelen-Gadea, M
Mallada, J
Carreres, J
Torres, LG
Dominguez, JA
Canizares, E
Gil-Perotin, S
Cubas, L
Rubio, RG
Castillo-Villalba, J
Perez-Miralles, FC
Casanova, B
author Vicente, CA
author_facet Vicente, CA
Lacruz, L
Gascon, F
Carratala, S
Quintanilla-Bordas, C
Sanz, MT
Carcelen-Gadea, M
Mallada, J
Carreres, J
Torres, LG
Dominguez, JA
Canizares, E
Gil-Perotin, S
Cubas, L
Rubio, RG
Castillo-Villalba, J
Perez-Miralles, FC
Casanova, B
author_role author
author2 Lacruz, L
Gascon, F
Carratala, S
Quintanilla-Bordas, C
Sanz, MT
Carcelen-Gadea, M
Mallada, J
Carreres, J
Torres, LG
Dominguez, JA
Canizares, E
Gil-Perotin, S
Cubas, L
Rubio, RG
Castillo-Villalba, J
Perez-Miralles, FC
Casanova, B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv OCMB
oligoclonal M bands
spinal cord
secondary progressive MS
multiple sclerosis
topic OCMB
oligoclonal M bands
spinal cord
secondary progressive MS
multiple sclerosis
description ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS). Methods276 CIS patients with a minimum follow-up of 10 years were studied. Baseline presence of oligoclonal IgG and IgM bands (OCGB and OCMB respectively); number of brain T2 lesions (B-T2L), brain gadolinium enhancement lesions (brain-GEL), cervical spinal cord T2 lesions (cSC-T2L); and fulfillment of 2017 McDonald criteria among other variables were collected. Results14 patients ended up with a non-MS condition. 138/276 CIS patients fulfilled 2017 McDonald criteria. Mean age was 32.4 years, 185 female. 227 received treatment, 95 as CIS. After a mean follow-up of 12 years, 36 patients developed SPMS. Conversion to SPMS was associated with OCGB (p = 0.02), OCMB (p = 0.0001); >= 9 B-T2L (p = 0.03), brain-GEL (p = 0.03), and cSC-T2L (p = 0.03). However, after adjusting for sex, age, BT2L, brain-GEL, SC-T2, and OCMB status, only OCMB (HR 4.4, 1.9-10.6) and cSC-T2L (HR 2.2, 1.0-6.2) suggested an independent association with risk of conversion to SPMS. Patients with both risk factors had a HR of 6.12 (2.8-12.9). DiscussionOCMB and SC-T2 lesions are potential independent predictors of conversion to SPMS.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/14670
url https://fisabio.portalinvestigacion.com/publicaciones/14670
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Neurology
ISSN: 16642295
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.812429

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