Oligoclonal M bands and cervical spinal cord lesions predict early secondary progressive multiple sclerosis

ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS). Methods276 CIS patients with a minimum follow-up of...

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Detalles Bibliográficos
Autores: Vicente, CA, Lacruz, L, Gascon, F, Carratala, S, Quintanilla-Bordas, C, Sanz, MT, Carcelen-Gadea, M, Mallada, J, Carreres, J, Torres, LG, Dominguez, JA, Canizares, E, Gil-Perotin, S, Cubas, L, Rubio, RG, Castillo-Villalba, J, Perez-Miralles, FC, Casanova, B
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p14670
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/14670
Access Level:acceso abierto
Palabra clave:OCMB
oligoclonal M bands
spinal cord
secondary progressive MS
multiple sclerosis
Descripción
Sumario:ObjectiveTo determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS). Methods276 CIS patients with a minimum follow-up of 10 years were studied. Baseline presence of oligoclonal IgG and IgM bands (OCGB and OCMB respectively); number of brain T2 lesions (B-T2L), brain gadolinium enhancement lesions (brain-GEL), cervical spinal cord T2 lesions (cSC-T2L); and fulfillment of 2017 McDonald criteria among other variables were collected. Results14 patients ended up with a non-MS condition. 138/276 CIS patients fulfilled 2017 McDonald criteria. Mean age was 32.4 years, 185 female. 227 received treatment, 95 as CIS. After a mean follow-up of 12 years, 36 patients developed SPMS. Conversion to SPMS was associated with OCGB (p = 0.02), OCMB (p = 0.0001); >= 9 B-T2L (p = 0.03), brain-GEL (p = 0.03), and cSC-T2L (p = 0.03). However, after adjusting for sex, age, BT2L, brain-GEL, SC-T2, and OCMB status, only OCMB (HR 4.4, 1.9-10.6) and cSC-T2L (HR 2.2, 1.0-6.2) suggested an independent association with risk of conversion to SPMS. Patients with both risk factors had a HR of 6.12 (2.8-12.9). DiscussionOCMB and SC-T2 lesions are potential independent predictors of conversion to SPMS.

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