Granuloprival cerebellar cortical degeneration in a and dog

Granuloprival degeneration is an uncommon form of cerebellar cortical degeneration (CCD). A 3-month-old Yorkshire Terrier and a 7-month-old Lagotto Romagnolo dog were presented with a history of progressive cerebellar dysfunction including wide-based stance, cerebellar ataxia, intention tremors, and...

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Authors: Mignan, Thomas|||0000-0002-7463-7069, Pumarola i Batlle, Martí|||0000-0002-0935-7941, Platt, Simon, James, Matthew, Pereira, Marta, Morey-Matamalas, Antonia, Recio, Alfredo
Format: article
Publication Date:2024
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:308623
Online Access:https://ddd.uab.cat/record/308623
https://dx.doi.org/urn:doi:10.1111/jvim.17091
Access Level:Open access
Keyword:Abiotrophy
Canine
Cerebellum
Degenerative
Granular cell
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spelling Granuloprival cerebellar cortical degeneration in a and dogMignan, Thomas|||0000-0002-7463-7069Pumarola i Batlle, Martí|||0000-0002-0935-7941Platt, SimonJames, MatthewPereira, MartaMorey-Matamalas, AntoniaRecio, AlfredoAbiotrophyCanineCerebellumDegenerativeGranular cellGranuloprival degeneration is an uncommon form of cerebellar cortical degeneration (CCD). A 3-month-old Yorkshire Terrier and a 7-month-old Lagotto Romagnolo dog were presented with a history of progressive cerebellar dysfunction including wide-based stance, cerebellar ataxia, intention tremors, and loss of menace response despite normal vision. Magnetic resonance imaging of the brain identified marked diffuse decrease of the cerebellum size. Euthanasia was performed in both cases because of progression of clinical signs. Histopathological examination identified marked diffuse thinning of the granular cell layer with almost complete loss of the granular cell neurons, providing a definitive diagnosis of granuloprival CCD. Granuloprival CCD should be considered as a differential diagnosis in Yorkshire Terrier and Lagotto Romagnolo dogs with post-natal progressive clinical signs of cerebellar dysfunction. 22024-01-0120242024-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/308623https://dx.doi.org/urn:doi:10.1111/jvim.17091reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3086232026-06-06T12:50:31Z
dc.title.none.fl_str_mv Granuloprival cerebellar cortical degeneration in a and dog
title Granuloprival cerebellar cortical degeneration in a and dog
spellingShingle Granuloprival cerebellar cortical degeneration in a and dog
Mignan, Thomas|||0000-0002-7463-7069
Abiotrophy
Canine
Cerebellum
Degenerative
Granular cell
title_short Granuloprival cerebellar cortical degeneration in a and dog
title_full Granuloprival cerebellar cortical degeneration in a and dog
title_fullStr Granuloprival cerebellar cortical degeneration in a and dog
title_full_unstemmed Granuloprival cerebellar cortical degeneration in a and dog
title_sort Granuloprival cerebellar cortical degeneration in a and dog
dc.creator.none.fl_str_mv Mignan, Thomas|||0000-0002-7463-7069
Pumarola i Batlle, Martí|||0000-0002-0935-7941
Platt, Simon
James, Matthew
Pereira, Marta
Morey-Matamalas, Antonia
Recio, Alfredo
author Mignan, Thomas|||0000-0002-7463-7069
author_facet Mignan, Thomas|||0000-0002-7463-7069
Pumarola i Batlle, Martí|||0000-0002-0935-7941
Platt, Simon
James, Matthew
Pereira, Marta
Morey-Matamalas, Antonia
Recio, Alfredo
author_role author
author2 Pumarola i Batlle, Martí|||0000-0002-0935-7941
Platt, Simon
James, Matthew
Pereira, Marta
Morey-Matamalas, Antonia
Recio, Alfredo
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Abiotrophy
Canine
Cerebellum
Degenerative
Granular cell
topic Abiotrophy
Canine
Cerebellum
Degenerative
Granular cell
description Granuloprival degeneration is an uncommon form of cerebellar cortical degeneration (CCD). A 3-month-old Yorkshire Terrier and a 7-month-old Lagotto Romagnolo dog were presented with a history of progressive cerebellar dysfunction including wide-based stance, cerebellar ataxia, intention tremors, and loss of menace response despite normal vision. Magnetic resonance imaging of the brain identified marked diffuse decrease of the cerebellum size. Euthanasia was performed in both cases because of progression of clinical signs. Histopathological examination identified marked diffuse thinning of the granular cell layer with almost complete loss of the granular cell neurons, providing a definitive diagnosis of granuloprival CCD. Granuloprival CCD should be considered as a differential diagnosis in Yorkshire Terrier and Lagotto Romagnolo dogs with post-natal progressive clinical signs of cerebellar dysfunction.
publishDate 2024
dc.date.none.fl_str_mv 2
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/308623
https://dx.doi.org/urn:doi:10.1111/jvim.17091
url https://ddd.uab.cat/record/308623
https://dx.doi.org/urn:doi:10.1111/jvim.17091
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
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