Smart Mesoporous Nanomaterials for Antitumor Therapy

The use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, transport and protect drug molecules until the target is...

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Detalhes bibliográficos
Autores: Martínez Carmona, Marina, Colilla Nieto, Montserrat, Vallet Regí, María Dulce Nombre
Formato: artículo
Fecha de publicación:2015
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/23077
Acesso em linha:https://hdl.handle.net/20.500.14352/23077
Access Level:acceso abierto
Palavra-chave:546
615.46
Mesoporous silica nanoparticles
Cancer treatment
Passive targeting
Active targeting
Stimuli-responsive
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
id ES_039c5c43637abdd5e1dcf8bdecd2b049
oai_identifier_str oai:docta.ucm.es:20.500.14352/23077
network_acronym_str ES
network_name_str España
repository_id_str
spelling Smart Mesoporous Nanomaterials for Antitumor TherapyMartínez Carmona, MarinaColilla Nieto, MontserratVallet Regí, María Dulce Nombre546615.46Mesoporous silica nanoparticlesCancer treatmentPassive targetingActive targetingStimuli-responsiveMaterialesQuímica inorgánica (Química)3312 Tecnología de Materiales2303 Química InorgánicaThe use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, transport and protect drug molecules until the target is reached. It is possible to incorporate different targeting ligands to the outermost surface of MSNs to selectively drive the drugs to the tumour tissues. To prevent the premature release of the cargo entrapped in the mesopores, it is feasible to cap the pore entrances using stimuli-responsive nanogates. Therefore, upon exposure to internal (pH, enzymes, glutathione, etc.) or external (temperature, light, magnetic field, etc.) stimuli, the pore opening takes place and the release of the entrapped cargo occurs. These smart MSNs are capable of selectively reaching and accumulating at the target tissue and releasing the entrapped drug in a specific and controlled fashion, constituting a promising alternative to conventional chemotherapy, which is typically associated with undesired side effects. In this review, we overview the recent advances reported by the scientific community in developing MSNs for antitumor therapy. We highlight the possibility to design multifunctional nanosystems using different therapeutic approaches aimed at increasing the efficacy of the antitumor treatment.MDPIUniversidad Complutense de Madrid20152015-12-0120152015-12-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/23077reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/230772026-06-02T12:44:21Z
dc.title.none.fl_str_mv Smart Mesoporous Nanomaterials for Antitumor Therapy
title Smart Mesoporous Nanomaterials for Antitumor Therapy
spellingShingle Smart Mesoporous Nanomaterials for Antitumor Therapy
Martínez Carmona, Marina
546
615.46
Mesoporous silica nanoparticles
Cancer treatment
Passive targeting
Active targeting
Stimuli-responsive
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
title_short Smart Mesoporous Nanomaterials for Antitumor Therapy
title_full Smart Mesoporous Nanomaterials for Antitumor Therapy
title_fullStr Smart Mesoporous Nanomaterials for Antitumor Therapy
title_full_unstemmed Smart Mesoporous Nanomaterials for Antitumor Therapy
title_sort Smart Mesoporous Nanomaterials for Antitumor Therapy
dc.creator.none.fl_str_mv Martínez Carmona, Marina
Colilla Nieto, Montserrat
Vallet Regí, María Dulce Nombre
author Martínez Carmona, Marina
author_facet Martínez Carmona, Marina
Colilla Nieto, Montserrat
Vallet Regí, María Dulce Nombre
author_role author
author2 Colilla Nieto, Montserrat
Vallet Regí, María Dulce Nombre
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 546
615.46
Mesoporous silica nanoparticles
Cancer treatment
Passive targeting
Active targeting
Stimuli-responsive
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
topic 546
615.46
Mesoporous silica nanoparticles
Cancer treatment
Passive targeting
Active targeting
Stimuli-responsive
Materiales
Química inorgánica (Química)
3312 Tecnología de Materiales
2303 Química Inorgánica
description The use of nanomaterials for the treatment of solid tumours is receiving increasing attention by the scientific community. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique features that make them suitable nanocarriers to host, transport and protect drug molecules until the target is reached. It is possible to incorporate different targeting ligands to the outermost surface of MSNs to selectively drive the drugs to the tumour tissues. To prevent the premature release of the cargo entrapped in the mesopores, it is feasible to cap the pore entrances using stimuli-responsive nanogates. Therefore, upon exposure to internal (pH, enzymes, glutathione, etc.) or external (temperature, light, magnetic field, etc.) stimuli, the pore opening takes place and the release of the entrapped cargo occurs. These smart MSNs are capable of selectively reaching and accumulating at the target tissue and releasing the entrapped drug in a specific and controlled fashion, constituting a promising alternative to conventional chemotherapy, which is typically associated with undesired side effects. In this review, we overview the recent advances reported by the scientific community in developing MSNs for antitumor therapy. We highlight the possibility to design multifunctional nanosystems using different therapeutic approaches aimed at increasing the efficacy of the antitumor treatment.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-12-01
2015
2015-12-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/23077
url https://hdl.handle.net/20.500.14352/23077
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300724

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