Resting-state EEG alpha/theta ratio related to neuropsychological test performance in Parkinson’s Disease

Objective To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson’s Disease (PD) non-demented patients. Methods 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the...

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Autores: Jaramillo-Jimenez, A. (Alberto)|||/items/501d62e2-1edc-44ea-b586-ad533b8a3879, Suarez-Revelo, J.X. (Jazmin Ximena)|||/items/e9159510-9153-4d37-ac9d-bc264a35a0e8, Ochoa-Gomez, J.F. (John Fredy)|||/items/54908892-e386-4564-a26c-7aef37603631, Carmona Arroyave, J.A. (Jairo Alexander)|||/items/09477b0c-a73d-4532-87d0-7cc18018e04f, Bocanegra, Y. (Yamile)|||/items/3d55b45e-dfdd-4497-b5b0-fa25cfb18c29, Lopera, F. (Francisco)|||/items/9b628a02-8fe7-4cce-abc3-9861832dd0b9, Buritica, O. (Omar)|||/items/21a4493d-a99e-4208-ae10-a15c68d1cbad, Pineda-Salazar, D.A. (David Antonio)|||/items/f2d0a97e-849f-4fba-bec7-2fb4801f01bd, Moreno-Gomez, L. (Leonardo)|||/items/d21ce35c-432b-46f2-9cf3-29aeecb85711, Tobon-Quintero, C.A. (Carlos Andres)|||/items/2e140374-4c93-4949-93e9-9a3916005f67, Borda-Borda, M.G. (Miguel German)|||/items/681ecdf1-0f23-4003-a702-417198fd228d, Bonanni, L. (Laura)|||/items/ba9f2f43-542c-4500-98a6-895b954f245a, Ffytche, D.H. (Dominic H.)|||/items/a0aa4bad-7cab-4971-bec1-d0a030c919f9, Bronnick, K. (Kolbjorn)|||/items/e1cd8b45-4824-4efd-9500-de85f9cd03c4, Aarsland, D. (Dag)|||/items/7f4024e7-2d11-43cf-8b41-29752ddf75e1
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universidad de Navarra
Repositorio:Dadun. Depósito Académico Digital de la Universidad de Navarra
Idioma:inglés
OAI Identifier:oai:dadun.unav.edu:10171/122831
Acceso en línea:https://hdl.handle.net/10171/122831
Access Level:acceso abierto
Palabra clave:Electroencephalography
Parkinson’s Disease
Alpha rhythm
Theta rhythm
Neuropsychological tests
Descripción
Sumario:Objective To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson’s Disease (PD) non-demented patients. Methods 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-state quantitative electroencephalogram (qEEG). Correlations between α/θ and performance in several neuropsychological tests were conducted, significant findings were included in a moderation analysis. Results The α/θ in all regions was lower in PD than in HC, with larger effect sizes in the posterior regions. Right parietal, and right and left occipital α/θ had significant positive correlations with performance in Judgement of Line Orientation Test (JLOT) in PD. Adjusted moderation analysis indicated that right, but not left, occipital α/θ influenced the JLOT performance related to PD. Conclusions Reduction of the occipital α/θ, in particular on the right side, was associated with visuospatial performance impairment in PD. Significance Visuospatial impairment in PD, which is highly correlated with the subsequent development of dementia, is reflected in α/θ in the right posterior regions. The right occipital α/θ may represent a useful qEEG marker for evaluating the presence of early signs of cognitive decline in PD and the subsequent risk of dementia.

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