Recommendations for the Clinical Approach to Immune Thrombocytopenia

Primary immune thrombocytopenia (ITP) is a complex autoimmune disease whose hallmark is a deregulation of cellular and humoral immunity leading to increased destruction and reduced production of platelets. The heterogeneity of presentation and clinical course hampers personalized approaches for diag...

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Authors: Mingot-Castellano, María Eva|||0000-0001-9083-855X, Canaro Hirnyk, Mariana, Sánchez González, Blanca, Álvarez-Román, María Teresa, Bárez-García, Abelardo|||0000-0001-8982-6105, Bernardo Gutiérrez, Ángel|||0000-0001-9711-8037, Bernat-Pablo, Silvia, Bolaños-Calderón, Estefanía, Butta-Coll, Nora|||0000-0003-4601-7150, Caballero-Navarro, Gonzalo, Caparrós-Miranda, Isabel Socorro, Entrena-Ureña, Laura, Fernández-Fuertes, Luis Fernando, García-Frade, Luis Javier, Gómez del Castillo, María del Carmen, González-López, Tomás José|||0000-0003-2458-2554, Grande-García, Carlos, Guinea de Castro, José María|||0000-0003-3285-0539, Jarque-Ramos, Isidro, Jiménez-Bárcenas, Reyes|||0000-0003-1968-1021, López-Ansoar, Elsa, Martínez-Carballeira, Daniel|||0000-0003-4840-7822, Martínez-Robles, Violeta, Monteagudo-Montesinos, Emilio, Páramo, Jose A.|||0000-0003-1497-6242, Perera-Álvarez, María del Mar, Soto-Ortega, Inmaculada, Valcárcel-Ferreiras, David, Pascual Izquierdo, Cristina
Format: article
Publication Date:2023
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:320334
Online Access:https://ddd.uab.cat/record/320334
https://dx.doi.org/urn:doi:10.3390/jcm12206422
Access Level:Open access
Keyword:Primary immune thrombocytopenia
Glucocorticoids
Intravenous immunoglobulins
Fostamatinib
Rituximab
Recommendations
Description
Summary:Primary immune thrombocytopenia (ITP) is a complex autoimmune disease whose hallmark is a deregulation of cellular and humoral immunity leading to increased destruction and reduced production of platelets. The heterogeneity of presentation and clinical course hampers personalized approaches for diagnosis and management. In 2021, the Spanish ITP Group (GEPTI) of the Spanish Society of Hematology and Hemotherapy (SEHH) updated a consensus document that had been launched in 2011. The updated guidelines have been the reference for the diagnosis and management of primary ITP in Spain ever since. Nevertheless, the emergence of new tools and strategies makes it advisable to review them again. For this reason, we have updated the main recommendations appropriately. Our aim is to provide a practical tool to facilitate the integral management of all aspects of primary ITP management.

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