A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials

In this investigation, a novel coating for viscose fabric surface modification was developed using a synergistic formulation between a natural antimicrobial cationic surfactant from lysine (MKM) and a biopolymer hyaluronic acid (HA). The interaction between MKM and HA in aqueous solutions, as well a...

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Autores: Bračič, Matej, Pérez, Lourdes, Infante, María Rosa, Kogej, Ksenija, Hribernik, Silvo, Šauperl, Olivera, Fras Zemljič, Lidija
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/131630
Acceso en línea:http://hdl.handle.net/10261/131630
Access Level:acceso abierto
Palabra clave:Antimicrobial activity
Viscose
Hyaluronic acid
Natural cationic surfactant
pH-potentiometric titration
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spelling A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materialsBračič, MatejPérez, LourdesInfante, María RosaKogej, KsenijaHribernik, SilvoŠauperl, OliveraFras Zemljič, LidijaAntimicrobial activityViscoseHyaluronic acidNatural cationic surfactantpH-potentiometric titrationIn this investigation, a novel coating for viscose fabric surface modification was developed using a synergistic formulation between a natural antimicrobial cationic surfactant from lysine (MKM) and a biopolymer hyaluronic acid (HA). The interaction between MKM and HA in aqueous solutions, as well as the interactions between their synergistic formulation (HA-MKM) and viscose fabric (CV) were studied using pH-potentiometric titrations', turbidity measurements, the Kjeldahl method for the determination of nitrogen amounts, attenuated total reflectance fourier transform infrared spectroscopy, and scanning electron microscopy. The hydrophilic and antimicrobial properties of the functionalised CV were examined in order to evaluate its usages for medical applications. The results of the interaction studies showed that MKM and HA interact with each other by forming a precipitate when the binding sites of HA are saturated. The precipitate has a slightly positive charge at neutral pH due to excess binding of the MKM to HA. The excess positive charge was also detected on CV coated with HA-MKM. This was proven to be very beneficial for the antimicrobial properties of the functionalised CV. The antimicrobial tests showed exceptional antimicrobial activity of the functionalised CV against Escherichia Coli, Staphylococcus Aureus, Streptococcus Agalactiae, Candida Albicans, and Candida Glabrata, making the CV fabric highly interesting for potential use in medicine. © 2014 Springer Science+Business Media Dordrecht.The financial support of Savatech d.o.o., Industrial rubber products and tyres is gratefully acknowledged. The authors also acknowledge the financial support from the Ministry of Education, Science and Sport of the Republic of Slovenia through the program P2 0118 as well l as ARRS project L2-4060 .and the financial support from Spanish Plan National I+D+I MAT2012-38047-C02-02.Peer reviewedSpringer NatureConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162014info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/131630reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1007/s10570-014-0338-8Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1316302026-05-22T06:33:51Z
dc.title.none.fl_str_mv A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
title A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
spellingShingle A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
Bračič, Matej
Antimicrobial activity
Viscose
Hyaluronic acid
Natural cationic surfactant
pH-potentiometric titration
title_short A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
title_full A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
title_fullStr A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
title_full_unstemmed A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
title_sort A novel synergistic formulation between a cationic surfactant from lysine and hyaluronic acid as an antimicrobial coating for advanced cellulose materials
dc.creator.none.fl_str_mv Bračič, Matej
Pérez, Lourdes
Infante, María Rosa
Kogej, Ksenija
Hribernik, Silvo
Šauperl, Olivera
Fras Zemljič, Lidija
author Bračič, Matej
author_facet Bračič, Matej
Pérez, Lourdes
Infante, María Rosa
Kogej, Ksenija
Hribernik, Silvo
Šauperl, Olivera
Fras Zemljič, Lidija
author_role author
author2 Pérez, Lourdes
Infante, María Rosa
Kogej, Ksenija
Hribernik, Silvo
Šauperl, Olivera
Fras Zemljič, Lidija
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Antimicrobial activity
Viscose
Hyaluronic acid
Natural cationic surfactant
pH-potentiometric titration
topic Antimicrobial activity
Viscose
Hyaluronic acid
Natural cationic surfactant
pH-potentiometric titration
description In this investigation, a novel coating for viscose fabric surface modification was developed using a synergistic formulation between a natural antimicrobial cationic surfactant from lysine (MKM) and a biopolymer hyaluronic acid (HA). The interaction between MKM and HA in aqueous solutions, as well as the interactions between their synergistic formulation (HA-MKM) and viscose fabric (CV) were studied using pH-potentiometric titrations', turbidity measurements, the Kjeldahl method for the determination of nitrogen amounts, attenuated total reflectance fourier transform infrared spectroscopy, and scanning electron microscopy. The hydrophilic and antimicrobial properties of the functionalised CV were examined in order to evaluate its usages for medical applications. The results of the interaction studies showed that MKM and HA interact with each other by forming a precipitate when the binding sites of HA are saturated. The precipitate has a slightly positive charge at neutral pH due to excess binding of the MKM to HA. The excess positive charge was also detected on CV coated with HA-MKM. This was proven to be very beneficial for the antimicrobial properties of the functionalised CV. The antimicrobial tests showed exceptional antimicrobial activity of the functionalised CV against Escherichia Coli, Staphylococcus Aureus, Streptococcus Agalactiae, Candida Albicans, and Candida Glabrata, making the CV fabric highly interesting for potential use in medicine. © 2014 Springer Science+Business Media Dordrecht.
publishDate 2014
dc.date.none.fl_str_mv 2014
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/131630
url http://hdl.handle.net/10261/131630
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1007/s10570-014-0338-8
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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