The multiomics blueprint of the individual with the most extreme lifespan

Torrubiano, Marta; Massip Salcedo, Marta; Khidir, Kamal A.; Cao, Thong Huy; Quinn, Paulene A.; Jones, Donald J. L.; Macip, Salvador; Brigos Barril, Eva; Moldes, Mauricio; Barteri, Fabio; Ferrer, Gerardo; Muntané, Gerard; Davalos, Veronica; Laayouni, Hafid; Mereu, Elisabetta; Navarro, Arcadi; Pluvinet, Raquel; Esteller, Manel; Arribas, Carles; Torre, Carolina de la; Villavicencio Goula, Francisco; Sumoy, Lauro; Granada, Isabel; Coles, Natalie S.; Santos Pujol, Eloy; Noguera Castells, Aleix; Casado Pelaez, Marta; García Prieto, Carlos A.; Vasallo, Claudia; Campillo Marcos, Ignacio; Quero Dotor, Carlos; Crespo García, Eva; Bueno Costa, Alberto; Setién, Fernando; Acha, Pamela; Solé, Francesc; Mallo, Mar; Mata, Caterina; Peregrina, Sara; Gabaldón, Toni; Llirós, Marc; Pujolassos, Meritxell; Carrera Torres, Robert; Lluansí, Aleix; García Gil, Librado Jesús; Aldeguer, Xavier; Samino, Sara; Torné, Pol; Ribalta, Josep; Guardiola, Montse; Amigó, Núria; Yanes, Oscar; Martínez, Paula; Sánchez Vázquez, Raúl; Blasco, Maria A.; Oviedo, Jose; Lemos, Bernardo; Rius Bonet, Julia

The multiomics blueprint of the individual with the most extreme lifespan

Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating h...

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Detalhes bibliográficos
Autores:	Torrubiano, Marta, Massip Salcedo, Marta, Khidir, Kamal A., Cao, Thong Huy, Quinn, Paulene A., Jones, Donald J. L., Macip, Salvador, Brigos Barril, Eva, Moldes, Mauricio, Barteri, Fabio, Ferrer, Gerardo, Muntané, Gerard, Davalos, Veronica, Laayouni, Hafid, Mereu, Elisabetta, Navarro, Arcadi, Pluvinet, Raquel, Esteller, Manel, Arribas, Carles, Torre, Carolina de la, Villavicencio Goula, Francisco, Sumoy, Lauro, Granada, Isabel, Coles, Natalie S., Santos Pujol, Eloy, Noguera Castells, Aleix, Casado Pelaez, Marta, García Prieto, Carlos A., Vasallo, Claudia, Campillo Marcos, Ignacio, Quero Dotor, Carlos, Crespo García, Eva, Bueno Costa, Alberto, Setién, Fernando, Acha, Pamela, Solé, Francesc, Mallo, Mar, Mata, Caterina, Peregrina, Sara, Gabaldón, Toni, Llirós, Marc, Pujolassos, Meritxell, Carrera Torres, Robert, Lluansí, Aleix, García Gil, Librado Jesús, Aldeguer, Xavier, Samino, Sara, Torné, Pol, Ribalta, Josep, Guardiola, Montse, Amigó, Núria, Yanes, Oscar, Martínez, Paula, Sánchez Vázquez, Raúl, Blasco, Maria A., Oviedo, Jose, Lemos, Bernardo, Rius Bonet, Julia
Tipo de documento:	artigo
Data de publicação:	2025
País:	España
Recursos:	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:	Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:	oai:recercat.cat:2445/227925
Acesso em linha:	https://hdl.handle.net/2445/227925
Access Level:	Acceso aberto
Palavra-chave:	Longevitat Envelliment Esperança de vida Longevity Aging Life expectancy

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spelling	The multiomics blueprint of the individual with the most extreme lifespanTorrubiano, MartaMassip Salcedo, MartaKhidir, Kamal A.Cao, Thong HuyQuinn, Paulene A.Jones, Donald J. L.Macip, SalvadorBrigos Barril, EvaMoldes, MauricioBarteri, FabioFerrer, GerardoMuntané, GerardDavalos, VeronicaLaayouni, HafidMereu, ElisabettaNavarro, ArcadiPluvinet, RaquelEsteller, ManelArribas, CarlesTorre, Carolina de laVillavicencio Goula, FranciscoSumoy, LauroGranada, IsabelColes, Natalie S.Santos Pujol, EloyNoguera Castells, AleixCasado Pelaez, MartaGarcía Prieto, Carlos A.Vasallo, ClaudiaCampillo Marcos, IgnacioQuero Dotor, CarlosCrespo García, EvaBueno Costa, AlbertoSetién, FernandoAcha, PamelaSolé, FrancescMallo, MarMata, CaterinaPeregrina, SaraGabaldón, ToniLlirós, MarcPujolassos, MeritxellCarrera Torres, RobertLluansí, AleixGarcía Gil, Librado JesúsAldeguer, XavierSamino, SaraTorné, PolRibalta, JosepGuardiola, MontseAmigó, NúriaYanes, OscarMartínez, PaulaSánchez Vázquez, RaúlBlasco, Maria A.Oviedo, JoseLemos, BernardoRius Bonet, JuliaLongevitatEnvellimentEsperança de vidaLongevityAgingLife expectancyExtreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.Cell Press2026202620252026info:eu-repo/semantics/articleinfo:eu-repo/semantics/PublishedVersion23 p.application/pdfhttps://hdl.handle.net/2445/227925Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.xcrm.2025.102368Cell Reports Medicine, 2025, vol. 6, num.10https://doi.org/10.1016/j.xcrm.2025.102368cc by-nc-nd (c) Torrubiano, Marta, et al, 2025https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2279252026-05-29T05:05:01Z
dc.title.none.fl_str_mv	The multiomics blueprint of the individual with the most extreme lifespan
title	The multiomics blueprint of the individual with the most extreme lifespan
spellingShingle	The multiomics blueprint of the individual with the most extreme lifespan Torrubiano, Marta Longevitat Envelliment Esperança de vida Longevity Aging Life expectancy
title_short	The multiomics blueprint of the individual with the most extreme lifespan
title_full	The multiomics blueprint of the individual with the most extreme lifespan
title_fullStr	The multiomics blueprint of the individual with the most extreme lifespan
title_full_unstemmed	The multiomics blueprint of the individual with the most extreme lifespan
title_sort	The multiomics blueprint of the individual with the most extreme lifespan
dc.creator.none.fl_str_mv	Torrubiano, Marta Massip Salcedo, Marta Khidir, Kamal A. Cao, Thong Huy Quinn, Paulene A. Jones, Donald J. L. Macip, Salvador Brigos Barril, Eva Moldes, Mauricio Barteri, Fabio Ferrer, Gerardo Muntané, Gerard Davalos, Veronica Laayouni, Hafid Mereu, Elisabetta Navarro, Arcadi Pluvinet, Raquel Esteller, Manel Arribas, Carles Torre, Carolina de la Villavicencio Goula, Francisco Sumoy, Lauro Granada, Isabel Coles, Natalie S. Santos Pujol, Eloy Noguera Castells, Aleix Casado Pelaez, Marta García Prieto, Carlos A. Vasallo, Claudia Campillo Marcos, Ignacio Quero Dotor, Carlos Crespo García, Eva Bueno Costa, Alberto Setién, Fernando Acha, Pamela Solé, Francesc Mallo, Mar Mata, Caterina Peregrina, Sara Gabaldón, Toni Llirós, Marc Pujolassos, Meritxell Carrera Torres, Robert Lluansí, Aleix García Gil, Librado Jesús Aldeguer, Xavier Samino, Sara Torné, Pol Ribalta, Josep Guardiola, Montse Amigó, Núria Yanes, Oscar Martínez, Paula Sánchez Vázquez, Raúl Blasco, Maria A. Oviedo, Jose Lemos, Bernardo Rius Bonet, Julia
author	Torrubiano, Marta
author_facet	Torrubiano, Marta Massip Salcedo, Marta Khidir, Kamal A. Cao, Thong Huy Quinn, Paulene A. Jones, Donald J. L. Macip, Salvador Brigos Barril, Eva Moldes, Mauricio Barteri, Fabio Ferrer, Gerardo Muntané, Gerard Davalos, Veronica Laayouni, Hafid Mereu, Elisabetta Navarro, Arcadi Pluvinet, Raquel Esteller, Manel Arribas, Carles Torre, Carolina de la Villavicencio Goula, Francisco Sumoy, Lauro Granada, Isabel Coles, Natalie S. Santos Pujol, Eloy Noguera Castells, Aleix Casado Pelaez, Marta García Prieto, Carlos A. Vasallo, Claudia Campillo Marcos, Ignacio Quero Dotor, Carlos Crespo García, Eva Bueno Costa, Alberto Setién, Fernando Acha, Pamela Solé, Francesc Mallo, Mar Mata, Caterina Peregrina, Sara Gabaldón, Toni Llirós, Marc Pujolassos, Meritxell Carrera Torres, Robert Lluansí, Aleix García Gil, Librado Jesús Aldeguer, Xavier Samino, Sara Torné, Pol Ribalta, Josep Guardiola, Montse Amigó, Núria Yanes, Oscar Martínez, Paula Sánchez Vázquez, Raúl Blasco, Maria A. Oviedo, Jose Lemos, Bernardo Rius Bonet, Julia
author_role	author
author2	Massip Salcedo, Marta Khidir, Kamal A. Cao, Thong Huy Quinn, Paulene A. Jones, Donald J. L. Macip, Salvador Brigos Barril, Eva Moldes, Mauricio Barteri, Fabio Ferrer, Gerardo Muntané, Gerard Davalos, Veronica Laayouni, Hafid Mereu, Elisabetta Navarro, Arcadi Pluvinet, Raquel Esteller, Manel Arribas, Carles Torre, Carolina de la Villavicencio Goula, Francisco Sumoy, Lauro Granada, Isabel Coles, Natalie S. Santos Pujol, Eloy Noguera Castells, Aleix Casado Pelaez, Marta García Prieto, Carlos A. Vasallo, Claudia Campillo Marcos, Ignacio Quero Dotor, Carlos Crespo García, Eva Bueno Costa, Alberto Setién, Fernando Acha, Pamela Solé, Francesc Mallo, Mar Mata, Caterina Peregrina, Sara Gabaldón, Toni Llirós, Marc Pujolassos, Meritxell Carrera Torres, Robert Lluansí, Aleix García Gil, Librado Jesús Aldeguer, Xavier Samino, Sara Torné, Pol Ribalta, Josep Guardiola, Montse Amigó, Núria Yanes, Oscar Martínez, Paula Sánchez Vázquez, Raúl Blasco, Maria A. Oviedo, Jose Lemos, Bernardo Rius Bonet, Julia
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Longevitat Envelliment Esperança de vida Longevity Aging Life expectancy
topic	Longevitat Envelliment Esperança de vida Longevity Aging Life expectancy
description	Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions.
publishDate	2025
dc.date.none.fl_str_mv	2025 2026 2026 2026
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/PublishedVersion
format	article
dc.identifier.none.fl_str_mv	https://hdl.handle.net/2445/227925
url	https://hdl.handle.net/2445/227925
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.relation.none.fl_str_mv	Versió postprint del document publicat a: https://doi.org/10.1016/j.xcrm.2025.102368 Cell Reports Medicine, 2025, vol. 6, num.10 https://doi.org/10.1016/j.xcrm.2025.102368
dc.rights.none.fl_str_mv	cc by-nc-nd (c) Torrubiano, Marta, et al, 2025 https://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess
rights_invalid_str_mv	cc by-nc-nd (c) Torrubiano, Marta, et al, 2025 https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	23 p. application/pdf
dc.publisher.none.fl_str_mv	Cell Press
publisher.none.fl_str_mv	Cell Press
dc.source.none.fl_str_mv	Articles publicats en revistes (Ciències Fisiològiques) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str	Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str	Recercat. Dipósit de la Recerca de Catalunya
collection	Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.81155

The multiomics blueprint of the individual with the most extreme lifespan

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