The multiomics blueprint of the individual with the most extreme lifespan

Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating h...

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Detalles Bibliográficos
Autores: Santos-Pujol, Eloy, Noguera Castells, Aleix, Casado-Pelaez, Marta, García-Prieto, Carlos A., Vasallo, Claudia, Campillo-Marcos, Ignacio, Quero-Dotor, Carlos, Crespo Garcia, Eva, Bueno-Costa, Alberto, Setién, Fernando, Ferrer, Gerardo, Davalos, Veronica, Mereu, Elisabetta, Pluvinet, Raquel, Arribas, Carles, Torre, Carolina de la, Villavicencio, Francisco, Sumoy, Lauro, Granada, Isabel, Coles, Natalie S., Acha, Pamela, Solé, Francesc, Mallo, Mar, Mata, Caterina, Peregrina, Sara, Gabaldón, Toni, Llirós Dupré, Marc, Pujolassos, Meritxell, Carreras-Torres, Robert, Lluansí Salis, Aleix, Garcia-Gil, L. J., Aldeguer i Manté, Xavier, Samino, Sara, Torné, Pol, Ribalta, Josep, Guardiola, Montse, Amigó, Núria, Yanes, Oscar, Martínez, Paula, Sánchez-Vázquez, Raúl, Blasco, Maria A., Oviedo, José, Lemos, Bernardo, Rius Bonet, Júlia, Torrubiano, Marta, Massip-Salcedo, Marta, Khidir, Kamal A., Cao, Thong H., Quinn, Paulene A., Jones, Donald J.L., Macip, Salvador, Brigos Barril, Eva, Moldes, Maurici, Barteri, Fabio, Muntané, Gerard, Laayouni, Hafid, Navarro, Arcadi, Esteller, Manel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10256/27677
Acceso en línea:http://hdl.handle.net/10256/27677
Access Level:acceso abierto
Palabra clave:Envelliment -- Aspectes genètics
Aging -- Genetic aspects
Persones centenàries
Centenarians
Epigenètica
Epigenetics
Genètica
Genetics
Genètica microbiana
Microbial genetics
Descripción
Sumario:Extreme human lifespan, exemplified by supercentenarians, presents a paradox in understanding aging: despite advanced age, they maintain relatively good health. To investigate this duality, we have performed a high-throughput multiomics study of the world's oldest living person, interrogating her genome, transcriptome, metabolome, proteome, microbiome, and epigenome, comparing the results with larger matched cohorts. The emerging picture highlights different pathways attributed to each process: the record-breaking advanced age is manifested by telomere attrition, abnormal B cell population, and clonal hematopoiesis, whereas absence of typical age-associated diseases is associated with rare European-population genetic variants, low inflammation levels, a rejuvenated bacteriome, and a younger epigenome. These findings provide a fresh look at human aging biology, suggesting biomarkers for healthy aging, and potential strategies to increase life expectancy. The extrapolation of our results to the general population will require larger cohorts and longitudinal prospective studies to design potential anti-aging interventions

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