Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA

We present a novel approach to reversibly control the assembly of liposomes through an anchored multistimuli responsive DNA oligonucleotide decorated with an azobenzene moiety (AZO-ON1). We show that liposomes assembly can be simultaneously controlled by three external stimuli: light, Mg2+, and temp...

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Detalhes bibliográficos
Autores: Hernández-Aínsa, Silvia, Ricci, Maria, Hilton, Lloyd, Aviñó, Anna, Eritja Casadellà, Ramón, Keyser, Ulrich Felix
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2016
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/137026
Acesso em linha:http://hdl.handle.net/10261/137026
Access Level:acceso abierto
Palavra-chave:Azobenzene
DNA
Liposomes
Self-assembly
Stimuli-responsive materials
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spelling Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNAHernández-Aínsa, SilviaRicci, MariaHilton, LloydAviñó, AnnaEritja Casadellà, RamónKeyser, Ulrich FelixAzobenzeneDNALiposomesSelf-assemblyStimuli-responsive materialsWe present a novel approach to reversibly control the assembly of liposomes through an anchored multistimuli responsive DNA oligonucleotide decorated with an azobenzene moiety (AZO-ON1). We show that liposomes assembly can be simultaneously controlled by three external stimuli: light, Mg2+, and temperature. (i) Light alters the interaction of AZO-ON1 with liposomes, which influences DNA coating and consequently liposomes assembly. (ii) Mg2+ induces the assembly, hence variation in its concentration enables for reversibility. (iii) Double-stranded AZO-ON1 is more efficient than single-stranded AZO-ON1 in triggering the assembly of liposomes and temperature has been used for controllable assembly through DNA thermal denaturation. Our multiresponsive AZO-ON1 represents a unique example in which multiple stimuli can be simultaneously applied to regulate the reversible assembly of liposomes. © 2016 American Chemical Society.S.H.A. acknowledges support from a Herchel Smith postdoctoral fellowship. M.R. acknowledges support from an Early Postdoc Mobility fellowship of Swiss National Science Foundation. A.A. and R.E. acknowledge support from MINECO, Spain, CTQ2014-52588-R. U.F.K. acknowledges support from an ERC Starting Grant Passmembrane 261101.Peer reviewedAmerican Chemical SocietyMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201620162016info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/137026reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttp://dx.doi.org/10.1021/acs.nanolett.6b01618Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1370262026-05-22T06:33:51Z
dc.title.none.fl_str_mv Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
title Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
spellingShingle Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
Hernández-Aínsa, Silvia
Azobenzene
DNA
Liposomes
Self-assembly
Stimuli-responsive materials
title_short Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
title_full Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
title_fullStr Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
title_full_unstemmed Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
title_sort Controlling the reversible assembly of liposomes through a multistimuli responsive anchored DNA
dc.creator.none.fl_str_mv Hernández-Aínsa, Silvia
Ricci, Maria
Hilton, Lloyd
Aviñó, Anna
Eritja Casadellà, Ramón
Keyser, Ulrich Felix
author Hernández-Aínsa, Silvia
author_facet Hernández-Aínsa, Silvia
Ricci, Maria
Hilton, Lloyd
Aviñó, Anna
Eritja Casadellà, Ramón
Keyser, Ulrich Felix
author_role author
author2 Ricci, Maria
Hilton, Lloyd
Aviñó, Anna
Eritja Casadellà, Ramón
Keyser, Ulrich Felix
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Azobenzene
DNA
Liposomes
Self-assembly
Stimuli-responsive materials
topic Azobenzene
DNA
Liposomes
Self-assembly
Stimuli-responsive materials
description We present a novel approach to reversibly control the assembly of liposomes through an anchored multistimuli responsive DNA oligonucleotide decorated with an azobenzene moiety (AZO-ON1). We show that liposomes assembly can be simultaneously controlled by three external stimuli: light, Mg2+, and temperature. (i) Light alters the interaction of AZO-ON1 with liposomes, which influences DNA coating and consequently liposomes assembly. (ii) Mg2+ induces the assembly, hence variation in its concentration enables for reversibility. (iii) Double-stranded AZO-ON1 is more efficient than single-stranded AZO-ON1 in triggering the assembly of liposomes and temperature has been used for controllable assembly through DNA thermal denaturation. Our multiresponsive AZO-ON1 represents a unique example in which multiple stimuli can be simultaneously applied to regulate the reversible assembly of liposomes. © 2016 American Chemical Society.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/137026
url http://hdl.handle.net/10261/137026
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv http://dx.doi.org/10.1021/acs.nanolett.6b01618
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Chemical Society
publisher.none.fl_str_mv American Chemical Society
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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