Calcium oscillations in cardiac cells with stochastic RyR2 dynamics
The study of the heart, due to its primordial relevance to human quality and expectancy of life, has taken tons of investigation efforts. In this sense, this work aims to contribute to this huge effort. We developed a stochastic computational model derived from the Marchena et al. minimal model of a...
| Autor: | |
|---|---|
| Tipo de documento: | dissertação |
| Data de publicação: | 2024 |
| País: | España |
| Recursos: | Universitat Politècnica de Catalunya (UPC) |
| Repositório: | UPCommons. Portal del coneixement obert de la UPC |
| Idioma: | inglês |
| OAI Identifier: | oai:upcommons.upc.edu:2117/423437 |
| Acesso em linha: | https://hdl.handle.net/2117/423437 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Stochastic models Calcium--Physiological effect Heart--Electric properties Calcium oscillations stochastic Calcio oscilaciones estocástico Models estocàstics Calci--Efectes fisiològics Cor--Propietats elèctriques Àrees temàtiques de la UPC::Matemàtiques i estadística::Estadística matemàtica::Modelització estadística |
| Resumo: | The study of the heart, due to its primordial relevance to human quality and expectancy of life, has taken tons of investigation efforts. In this sense, this work aims to contribute to this huge effort. We developed a stochastic computational model derived from the Marchena et al. minimal model of a cardiac cell with the objective of study the emergence of calcium oscillations, a potentially harmful phenomenon liked to cardiac arrhythmia. Under constant homeostatic conditions, we performed simulations at zero, one, and two dimensions, in order to analyse the conditions at which these oscillations emerge and vanish and its properties. Within the zero-dimensional framework, the stochastic model has able to reproduce the outcomes given by the Marchena et al model. However no satisfactory results were obtained within the one-dimensional framework as all cases out of the deterministic homogenous ideal cases, end up in perpetually stationary system. In contrast, the two-dimensional model showed fading coordinated oscillations even with inhomogeneous conditions. As the two-dimensional case allowing the emergence of rapidly fading oscillations, we can deduce that further refinement is need in spatial characterization and RyR2 modelling to overcome the instabilities found, being 3D modelling one possibility of improvement. |
|---|