Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas

Intratumor heterogeneity (ITH) is a constant evolutionary event in all malignant tumors, and clear cell renal cell carcinoma (CCRCC) is a paradigmatic example. ITH is responsible for most therapeutic failures in the era of precision oncology, so its precise detection remains a must in modern medicin...

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Detalles Bibliográficos
Autores: Manini, Claudia, López Fernández Villaverde, Estíbaliz, López, José Ignacio
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/11542
Acceso en línea:http://hdl.handle.net/11268/11542
Access Level:acceso abierto
Palabra clave:Carcinoma de células renales
Cáncer
Muestreo
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spelling Towards Personalized Sampling in Clear Cell Renal Cell CarcinomasManini, ClaudiaLópez Fernández Villaverde, EstíbalizLópez, José IgnacioCarcinoma de células renalesCáncerMuestreoIntratumor heterogeneity (ITH) is a constant evolutionary event in all malignant tumors, and clear cell renal cell carcinoma (CCRCC) is a paradigmatic example. ITH is responsible for most therapeutic failures in the era of precision oncology, so its precise detection remains a must in modern medicine. Unfortunately, classic sampling protocols do not resolve the problem as expected and several strategies have been being implemented in recent years to improve such detection. Basically, multisite tumor sampling (MSTS) and the homogenization of the residual tumor tissue are on display. A next step of the MSTS strategy considering the recently discovered patterns of ITH regionalization is presented here, the so-called personalized MSTS (pMSTS). This modification consists of paying more attention to sample the tumor periphery since it is this area with maximum levels of ITH.20222022-07-2820222022-01-0120222022-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/11268/11542reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/115422026-06-11T12:41:27Z
dc.title.none.fl_str_mv Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
title Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
spellingShingle Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
Manini, Claudia
Carcinoma de células renales
Cáncer
Muestreo
title_short Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
title_full Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
title_fullStr Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
title_full_unstemmed Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
title_sort Towards Personalized Sampling in Clear Cell Renal Cell Carcinomas
dc.creator.none.fl_str_mv Manini, Claudia
López Fernández Villaverde, Estíbaliz
López, José Ignacio
author Manini, Claudia
author_facet Manini, Claudia
López Fernández Villaverde, Estíbaliz
López, José Ignacio
author_role author
author2 López Fernández Villaverde, Estíbaliz
López, José Ignacio
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Carcinoma de células renales
Cáncer
Muestreo
topic Carcinoma de células renales
Cáncer
Muestreo
description Intratumor heterogeneity (ITH) is a constant evolutionary event in all malignant tumors, and clear cell renal cell carcinoma (CCRCC) is a paradigmatic example. ITH is responsible for most therapeutic failures in the era of precision oncology, so its precise detection remains a must in modern medicine. Unfortunately, classic sampling protocols do not resolve the problem as expected and several strategies have been being implemented in recent years to improve such detection. Basically, multisite tumor sampling (MSTS) and the homogenization of the residual tumor tissue are on display. A next step of the MSTS strategy considering the recently discovered patterns of ITH regionalization is presented here, the so-called personalized MSTS (pMSTS). This modification consists of paying more attention to sample the tumor periphery since it is this area with maximum levels of ITH.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-07-28
2022
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/11542
url http://hdl.handle.net/11268/11542
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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