Pure sarcomatous recurrence of clear cell renal carcinoma following radical nephrectomy and dendritic cell vaccination

CONTEXT: Sarcomatous differentiation, which represents transformation to high-grade malig- nancy, can occur in all histogical types of renal malignancy. CASE REPORT: The authors report on the case of a 66-year-old woman with a right renal mass that was shown to be a clear cell carcinoma. She un- der...

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Detalles Bibliográficos
Autores: Antunes, Alberto Azoubel, Dall’Oglio, Marcos Francisco, Barbuto, José Alexandre Marzagão, Leite, Kátia Ramos Moreira, Srougi, Miguel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2006
País:Brasil
Institución:Associação Paulista de Medicina
Repositorio:São Paulo medical journal (Online)
Idioma:inglés
OAI Identifier:oai:ojs.diagnosticoetratamento.emnuvens.com.br:article/2224
Acceso en línea:https://periodicosapm.emnuvens.com.br/spmj/article/view/2224
Access Level:acceso abierto
Palabra clave:Carcinoma de células renais
Recidiva
Sarcoma
Nefrectomia
Células dendríticas
Renal cell carcinoma
Recurrence
Nephrectomy
Dendritic cells
Descripción
Sumario:CONTEXT: Sarcomatous differentiation, which represents transformation to high-grade malig- nancy, can occur in all histogical types of renal malignancy. CASE REPORT: The authors report on the case of a 66-year-old woman with a right renal mass that was shown to be a clear cell carcinoma. She un- derwent radical nephrectomy and dendritic cell vaccination and, 3.5 years later, she developed retroperitoneal pure sarcomatous recurrence of the tumor. The authors speculate that the vaccination could have played some role in this differentiation or selection of the sarcomatous component of the primary tumor.