An Electrophilic Bromine Redox Catalysis Manifold for Indole Alkaloid Building Blocks from Selective Aliphatic C-H Amination

A new homogeneous bromine(-I/I) redox catalysis is described, which is based on monomeric bromine(I) compounds containing transferable phthalimidato groups. These catalysts enable intermolecular C-H amination reactions at previously unaccessible aliphatic positions and thus enlarge the synthetic pot...

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Detalles Bibliográficos
Autores: Bergès, Julien, García, Belén, Muñiz, Kilian
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2072/356011
Acceso en línea:http://hdl.handle.net/2072/356011
https://doi.org/10.1002/anie.201808939
Access Level:acceso abierto
Palabra clave:54
Descripción
Sumario:A new homogeneous bromine(-I/I) redox catalysis is described, which is based on monomeric bromine(I) compounds containing transferable phthalimidato groups. These catalysts enable intermolecular C-H amination reactions at previously unaccessible aliphatic positions and thus enlarge the synthetic potential of direct C- N bond formation including its application in alkaloid building block synthesis. This aspect is demonstrated for a new synthetic approach to aspidospermidine. In addition to the catalysis development, the structures of the involved bromine(I) key catalysts were fully elucidated including X-ray analyses.