Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination

[Significance]: The present study highlights a fundamental role of GABAergic interneuron-derived Reelin in neuronal migration, in addition to CR cell–expressed Reelin. Further, we observed transient migratory deficits, indicating that Reelin expressed by either neuronal population is sufficient to r...

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Bibliographic Details
Authors: Vílchez-Acosta, Alba, Manso, Yasmina, Cárdenas, Adrián, Elias-Tersa, Alba, Martínez-Losa, Magdalena, Pascual, Marta, Álvarez-Dolado, Manuel, Nairn, Angus C., Borrell, Víctor, Soriano, Eduardo
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Consejo Superior de Investigaciones Científicas (CSIC)
Repository:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/286347
Online Access:http://hdl.handle.net/10261/286347
Access Level:Open access
Description
Summary:[Significance]: The present study highlights a fundamental role of GABAergic interneuron-derived Reelin in neuronal migration, in addition to CR cell–expressed Reelin. Further, we observed transient migratory deficits, indicating that Reelin expressed by either neuronal population is sufficient to reverse some lamination defects. We propose a model of Reelin action in corticogenesis based on the spatial and cell-specific expression of this key protein. Because several neuropsychiatric disorders are linked to Reelin deficits in interneurons, this study may provide a better understanding of the mechanisms associated with human brain disorders related to Reelin deficits.

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