Specific contribution of Reelin expressed by Cajal-Retzius cells or GABAergic interneurons to cortical lamination

[Significance]: The present study highlights a fundamental role of GABAergic interneuron-derived Reelin in neuronal migration, in addition to CR cell–expressed Reelin. Further, we observed transient migratory deficits, indicating that Reelin expressed by either neuronal population is sufficient to r...

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Detalles Bibliográficos
Autores: Vílchez-Acosta, Alba, Manso, Yasmina, Cárdenas, Adrián, Elias-Tersa, Alba, Martínez-Losa, Magdalena, Pascual, Marta, Álvarez-Dolado, Manuel, Nairn, Angus C., Borrell, Víctor, Soriano, Eduardo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/286347
Acceso en línea:http://hdl.handle.net/10261/286347
Access Level:acceso abierto
Descripción
Sumario:[Significance]: The present study highlights a fundamental role of GABAergic interneuron-derived Reelin in neuronal migration, in addition to CR cell–expressed Reelin. Further, we observed transient migratory deficits, indicating that Reelin expressed by either neuronal population is sufficient to reverse some lamination defects. We propose a model of Reelin action in corticogenesis based on the spatial and cell-specific expression of this key protein. Because several neuropsychiatric disorders are linked to Reelin deficits in interneurons, this study may provide a better understanding of the mechanisms associated with human brain disorders related to Reelin deficits.