Nanoazitromicina preparada por el método solvente/ antisolvente: efecto sobre la disolución
Azithromycin belongs to group II of the biopharmaceutical classification system, its low aqueous solubility explains itspoor bioavailability. The purpose of the present work was to develop a Nano suspension of azithromycin by the solvent/ antisolvent method to improve its dissolution speed, for this...
| Autores: | , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | Ecuador |
| Institución: | Universidad Central del Ecuador |
| Repositorio: | Revista Química central |
| Idioma: | español |
| OAI Identifier: | oai:revistadigital.uce.edu.ec:article/1412 |
| Acceso en línea: | https://revistadigital.uce.edu.ec/index.php/QUIMICA/article/view/1412 |
| Access Level: | acceso abierto |
| Palabra clave: | nanosuspensión azitromicina solvente / antisolvente nanosuspension azithromycin solvent / antisolvent |
| Sumario: | Azithromycin belongs to group II of the biopharmaceutical classification system, its low aqueous solubility explains itspoor bioavailability. The purpose of the present work was to develop a Nano suspension of azithromycin by the solvent/ antisolvent method to improve its dissolution speed, for this, the influence of the temperature of the dispersion meanswas determined. An ethanolic solution of azithromycin (200 mg / ml) was added at a rate of 100 ul / s, on an aqueoussolution of tween 80 (4.5 mg / ml) at 0, 25 and 80°C. Azithromycin nanoparticles of 268.2 nm were obtained, with apolydispersity index of 0.396, Z potential of -39.6 mV and 94.2% purity. With them, powder was made to reconstituteoral suspension using hydroxyethyl cellulose as a protective colloid and xanthan gum as a viscosifier. The dissolutionspeed of azithromycin nanoparticles is almost 400% higher than azithromycin powder. |
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