Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice

Microfiltered noni (Morinda citrifolia) juice was given by cannulation to 6 Wistar rats for 13 days; the rats were also fed on a standard food formulation containing whole soy bean flour. Twenty-four hour urine was collected before and after the nutritional intervention and was analyzed by UPLC-DAD/...

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Detalles Bibliográficos
Autores: Fallas Ramírez, José Manuel, Hernández Gómez, Lorena, Vaillant Barka, Fabrice
Tipo de recurso: artículo
Fecha de publicación:2018
País:Costa Rica
Institución:Universidad de Costa Rica
Repositorio:Kérwá
Idioma:inglés
OAI Identifier:oai:kerwa.ucr.ac.cr:10669/86118
Acceso en línea:https://www.sciencedirect.com/science/article/abs/pii/S175646461730645X?via%3Dihub
https://hdl.handle.net/10669/86118
Access Level:acceso abierto
Palabra clave:Metabolomic
Isoflavone
Equol
Daidzein
Morinda citrifolia
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spelling Fallas Ramírez, José Manuelfb792e42-9f8b-4189-b3ad-448c3b494909600Hernández Gómez, Lorenaa6ce193e-7006-42ff-b531-e8dda9e28363600Vaillant Barka, Fabriced13d197c-1a39-4aa2-b3dc-57dc5304458c6002022-03-16T13:17:43Z2022-03-16T13:17:43Z20182150https://www.sciencedirect.com/science/article/abs/pii/S175646461730645X?via%3Dihub1756-4646https://hdl.handle.net/10669/8611810.1016/j.jff.2017.10.034735-A2-502735-A6-912Microfiltered noni (Morinda citrifolia) juice was given by cannulation to 6 Wistar rats for 13 days; the rats were also fed on a standard food formulation containing whole soy bean flour. Twenty-four hour urine was collected before and after the nutritional intervention and was analyzed by UPLC-DAD/ESI+-QTof/MS to perform an untargeted metabolomics study. A supervised multivariate OSC-PLS-DA analysis was performed to discriminate between urine samples. Among the top 10 most discriminant ions, 8 compounds were tentatively identified. Six were significantly increased after noni juice ingestion: the glucuronidate form of S-(-) equol, daidzein, 2 isomers of dihydroxyquinoline, naphthyl and hippuric acid. On the contrary, the urinary excretion of the oligosaccharides stachyose and raffinose, was significantly reduced. Still highly statistically significant, glucuronated genistein and glycetein were also elevated in urine after noni juice ingestion. Noni juice appeared to considerably enhance the bioavailability of soy isoflavone and modify the metabolism of soy oligosaccharides.Universidad de Costa Rica/[735-A2-502]/UCR/Costa RicaUniversidad de Costa Rica/[735-A6-912]/UCR/Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Agroalimentarias::Centro Nacional de Ciencia y Tecnología de Alimentos (CITA)UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigaciones en Productos Naturales (CIPRONA)UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Instituto de Investigaciones Farmacéuticas (INIFAR)51-59engacceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessJournal of Functional Foods, 40, pp. 51-59reponame:Kérwáinstname:Universidad de Costa Ricainstacron:UCRMetabolomicIsoflavoneEquolDaidzeinMorinda citrifoliaUntargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juiceartículo originalhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleORIGINALCITA_Artículo_Untargeted metabolomic profiling of urine.pdfCITA_Artículo_Untargeted metabolomic profiling of urine.pdfapplication/pdf601152https://www.kerwa.ucr.ac.cr/bitstreams/2059772c-367f-4d61-9835-7dd4efc52528/download8390d0c15adb32fdf8598ce70b804b81MD51THUMBNAILCITA_Artículo_Untargeted metabolomic profiling of urine.pdf.jpgCITA_Artículo_Untargeted metabolomic profiling of urine.pdf.jpgIM Thumbnailimage/jpeg12505https://www.kerwa.ucr.ac.cr/bitstreams/f9f34718-19ac-47ed-a9eb-f09771635d77/downloadaefb18760ef3a7a3d7e9b8b62e91c2ddMD52TEXTCITA_Artículo_Untargeted metabolomic profiling of urine.pdf.txtCITA_Artículo_Untargeted metabolomic profiling of urine.pdf.txtExtracted texttext/plain56815https://www.kerwa.ucr.ac.cr/bitstreams/0d2bd5c8-2600-4cdb-93f4-94faec3b98ad/download6458f17ab6075a3c41e113aca22d15dcMD5310669/861182024-08-22 05:38:14.855embargo2150-01-01oai:kerwa.ucr.ac.cr:10669/86118https://www.kerwa.ucr.ac.crInstitucionalhttp://www.kerwa.ucr.ac.crUniversidadhttp://www.ucr.ac.crhttps://kerwa.ucr.ac.cr/oai/requestmeilyn.garro@ucr.ac.crCosta RicaNo aplicaNo aplicaNo aplicaopendoar:18712025-03-29T18:07:20.150Kérwá - Universidad de Costa Ricafalse
dc.title.en.fl_str_mv Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
title Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
spellingShingle Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
Fallas Ramírez, José Manuel
Metabolomic
Isoflavone
Equol
Daidzein
Morinda citrifolia
title_short Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
title_full Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
title_fullStr Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
title_full_unstemmed Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
title_sort Untargeted metabolomic profiling of urine in Wistar rats reveals enhanced bioavailability of soy isoflavones post short-term consumption of noni (Morinda citrifolia) juice
dc.creator.none.fl_str_mv Fallas Ramírez, José Manuel
Hernández Gómez, Lorena
Vaillant Barka, Fabrice
author Fallas Ramírez, José Manuel
author_facet Fallas Ramírez, José Manuel
Hernández Gómez, Lorena
Vaillant Barka, Fabrice
author_role author
author2 Hernández Gómez, Lorena
Vaillant Barka, Fabrice
author2_role author
author
dc.subject.en.fl_str_mv Metabolomic
Isoflavone
Equol
Daidzein
Morinda citrifolia
topic Metabolomic
Isoflavone
Equol
Daidzein
Morinda citrifolia
description Microfiltered noni (Morinda citrifolia) juice was given by cannulation to 6 Wistar rats for 13 days; the rats were also fed on a standard food formulation containing whole soy bean flour. Twenty-four hour urine was collected before and after the nutritional intervention and was analyzed by UPLC-DAD/ESI+-QTof/MS to perform an untargeted metabolomics study. A supervised multivariate OSC-PLS-DA analysis was performed to discriminate between urine samples. Among the top 10 most discriminant ions, 8 compounds were tentatively identified. Six were significantly increased after noni juice ingestion: the glucuronidate form of S-(-) equol, daidzein, 2 isomers of dihydroxyquinoline, naphthyl and hippuric acid. On the contrary, the urinary excretion of the oligosaccharides stachyose and raffinose, was significantly reduced. Still highly statistically significant, glucuronated genistein and glycetein were also elevated in urine after noni juice ingestion. Noni juice appeared to considerably enhance the bioavailability of soy isoflavone and modify the metabolism of soy oligosaccharides.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2022-03-16T13:17:43Z
dc.date.available.none.fl_str_mv 2022-03-16T13:17:43Z
dc.date.embargoedUntil.none.fl_str_mv 2150
dc.type.none.fl_str_mv artículo original
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info:eu-repo/semantics/article
format article
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dc.identifier.issn.none.fl_str_mv 1756-4646
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10669/86118
dc.identifier.doi.none.fl_str_mv 10.1016/j.jff.2017.10.034
dc.identifier.codproyecto.none.fl_str_mv 735-A2-502
735-A6-912
url https://www.sciencedirect.com/science/article/abs/pii/S175646461730645X?via%3Dihub
https://hdl.handle.net/10669/86118
identifier_str_mv 1756-4646
10.1016/j.jff.2017.10.034
735-A2-502
735-A6-912
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv acceso abierto
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info:eu-repo/semantics/openAccess
rights_invalid_str_mv acceso abierto
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.extent.none.fl_str_mv 51-59
dc.source.none.fl_str_mv Journal of Functional Foods, 40, pp. 51-59
reponame:Kérwá
instname:Universidad de Costa Rica
instacron:UCR
instname_str Universidad de Costa Rica
instacron_str UCR
institution UCR
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