Elastosis in Actinic Cheilitis. Literature Review

The extracellular matrix (ECM) plays an important role in the regulation of biological events, such as cell migration, proliferation and differentiation. Chronic exposure to ultraviolet (UV) light causes elastosis (to varying degrees), which corresponds to a basophilic degeneration of the ECM. Actin...

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Authors: Boza Oreamuno DDS, MSc, Yadira V., Rojas DDS, PhD, Isolde G.
Format: article
Status:Published version
Publication Date:2018
Country:Costa Rica
Institution:Universidad de Costa Rica
Repository:Portal de Revistas UCR
Language:English
OAI Identifier:oai:portal.ucr.ac.cr:article/32590
Online Access:https://revistas.ucr.ac.cr/index.php/Odontos/article/view/32590
Access Level:Open access
Keyword:Actinic cheilitis
Actinic elastosis
Photodamage
Lip
Mast cell
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spelling Elastosis in Actinic Cheilitis. Literature ReviewBoza Oreamuno DDS, MSc, Yadira V.Rojas DDS, PhD, Isolde G.Actinic cheilitisActinic elastosisPhotodamageLipMast cellThe extracellular matrix (ECM) plays an important role in the regulation of biological events, such as cell migration, proliferation and differentiation. Chronic exposure to ultraviolet (UV) light causes elastosis (to varying degrees), which corresponds to a basophilic degeneration of the ECM. Actinic cheilitis (AC) is a potentially malignant lip lesion induced by regular and prolonged exposure to UV light, which mainly affects the vermilion. AC lesions have a complex stroma characterized by the presence of elastosis, chronic inflammatory infiltrate of different intensity and the appearance of telangiectatic blood vessels. Within this inflammatory infiltrate a significant increase of mast cells (MCs) has been described, located especially around areas of elastosis and at the subepithelial zone. It has been proposed that actinic elastosis is produced both, by degenerative processes and by abnormal synthesis of elastic fibers by photodamaged fibroblasts, which is accompanied by morphological changes in collagen. Although the fibroblast would play a major role in actinic elastosis formation, several studies suggest that other cell types such as MCs also contribute significantly to actinic ECM damage. The purpose of this review is to discuss the characteristics of elastosis in AC.Universidad de Costa Rica2018-05-21info:eu-repo/semantics/publishedVersionContributionLiterature review articlesartículo originalhttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdftext/htmlhttps://revistas.ucr.ac.cr/index.php/Odontos/article/view/3259010.15517/ijds.v20i2.32590Odovtos - International Journal of Dental Sciences; Vol. 20 No. 2 (2018): (May-August) ODOVTOS - International Journal of Dental Sciences; 51-60Odovtos International Journal of Dental Sciences; Vol. 20 Núm. 2 (2018): (May-August) ODOVTOS - International Journal of Dental Sciences; 51-602215-34111659-104610.15517/ijds.v20i2reponame:Portal de Revistas UCRinstname:Universidad de Costa Ricainstacron:UCRenghttps://revistas.ucr.ac.cr/index.php/Odontos/article/view/32590/32168https://revistas.ucr.ac.cr/index.php/Odontos/article/view/32590/32175Derechos de autor 2018 Odovtos International Journal of Dental Sciencesacceso abiertohttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccess2021-06-09T22:09:56Zoai:portal.ucr.ac.cr:article/32590Portal de revistashttps://revistas.ucr.ac.cr/Universidadhttp://www.ucr.ac.crhttps://revistas.ucr.ac.cr/index.php/index/oaijorge.polanco@ucr.ac.crCosta RicaNo aplicaNo aplicaNo aplicaopendoar:2025-08-13T10:44:01.304Portal de Revistas UCR - Universidad de Costa Ricafalse
dc.title.none.fl_str_mv Elastosis in Actinic Cheilitis. Literature Review
title Elastosis in Actinic Cheilitis. Literature Review
spellingShingle Elastosis in Actinic Cheilitis. Literature Review
Boza Oreamuno DDS, MSc, Yadira V.
Actinic cheilitis
Actinic elastosis
Photodamage
Lip
Mast cell
title_short Elastosis in Actinic Cheilitis. Literature Review
title_full Elastosis in Actinic Cheilitis. Literature Review
title_fullStr Elastosis in Actinic Cheilitis. Literature Review
title_full_unstemmed Elastosis in Actinic Cheilitis. Literature Review
title_sort Elastosis in Actinic Cheilitis. Literature Review
dc.creator.none.fl_str_mv Boza Oreamuno DDS, MSc, Yadira V.
Rojas DDS, PhD, Isolde G.
author Boza Oreamuno DDS, MSc, Yadira V.
author_facet Boza Oreamuno DDS, MSc, Yadira V.
Rojas DDS, PhD, Isolde G.
author_role author
author2 Rojas DDS, PhD, Isolde G.
author2_role author
dc.subject.none.fl_str_mv Actinic cheilitis
Actinic elastosis
Photodamage
Lip
Mast cell
topic Actinic cheilitis
Actinic elastosis
Photodamage
Lip
Mast cell
description The extracellular matrix (ECM) plays an important role in the regulation of biological events, such as cell migration, proliferation and differentiation. Chronic exposure to ultraviolet (UV) light causes elastosis (to varying degrees), which corresponds to a basophilic degeneration of the ECM. Actinic cheilitis (AC) is a potentially malignant lip lesion induced by regular and prolonged exposure to UV light, which mainly affects the vermilion. AC lesions have a complex stroma characterized by the presence of elastosis, chronic inflammatory infiltrate of different intensity and the appearance of telangiectatic blood vessels. Within this inflammatory infiltrate a significant increase of mast cells (MCs) has been described, located especially around areas of elastosis and at the subepithelial zone. It has been proposed that actinic elastosis is produced both, by degenerative processes and by abnormal synthesis of elastic fibers by photodamaged fibroblasts, which is accompanied by morphological changes in collagen. Although the fibroblast would play a major role in actinic elastosis formation, several studies suggest that other cell types such as MCs also contribute significantly to actinic ECM damage. The purpose of this review is to discuss the characteristics of elastosis in AC.
publishDate 2018
dc.date.none.fl_str_mv 2018-05-21
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
Contribution
Literature review articles
artículo original
http://purl.org/coar/resource_type/c_2df8fbb1
info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.ucr.ac.cr/index.php/Odontos/article/view/32590
10.15517/ijds.v20i2.32590
url https://revistas.ucr.ac.cr/index.php/Odontos/article/view/32590
identifier_str_mv 10.15517/ijds.v20i2.32590
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistas.ucr.ac.cr/index.php/Odontos/article/view/32590/32168
https://revistas.ucr.ac.cr/index.php/Odontos/article/view/32590/32175
dc.rights.none.fl_str_mv Derechos de autor 2018 Odovtos International Journal of Dental Sciences
acceso abierto
http://purl.org/coar/access_right/c_abf2
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2018 Odovtos International Journal of Dental Sciences
acceso abierto
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
dc.publisher.none.fl_str_mv Universidad de Costa Rica
publisher.none.fl_str_mv Universidad de Costa Rica
dc.source.none.fl_str_mv Odovtos - International Journal of Dental Sciences; Vol. 20 No. 2 (2018): (May-August) ODOVTOS - International Journal of Dental Sciences; 51-60
Odovtos International Journal of Dental Sciences; Vol. 20 Núm. 2 (2018): (May-August) ODOVTOS - International Journal of Dental Sciences; 51-60
2215-3411
1659-1046
10.15517/ijds.v20i2
reponame:Portal de Revistas UCR
instname:Universidad de Costa Rica
instacron:UCR
instname_str Universidad de Costa Rica
instacron_str UCR
institution UCR
reponame_str Portal de Revistas UCR
collection Portal de Revistas UCR
repository.name.fl_str_mv Portal de Revistas UCR - Universidad de Costa Rica
repository.mail.fl_str_mv jorge.polanco@ucr.ac.cr
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score 15,812455

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