Vertical Transmission in a Two-Strain Model of Dengue Fever
The role of vertical transmission in vectors has rarely been addressed in the study of dengue dynamics and control, in part because it was not considered a critical population-level factor. In this paper, we apply the pioneering model- ing ideas of Ross and MacDonald, motivated by the context of the...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2014 |
| País: | Costa Rica |
| Institución: | Universidad de Costa Rica |
| Repositorio: | Kérwá |
| OAI Identifier: | oai:kerwa.ucr.ac.cr:10669/75903 |
| Acceso en línea: | https://www.tandfonline.com/doi/abs/10.1080/23737867.2014.11414484 https://hdl.handle.net/10669/75903 |
| Access Level: | acceso embargado |
| Palabra clave: | Modelo matemático Modelos epidémicos Matemática aplicada Dengue Transmisión vertical Vector-host model Epidemiology Vertical transmission Peru 616.921 Fiebre de dengue |
| Sumario: | The role of vertical transmission in vectors has rarely been addressed in the study of dengue dynamics and control, in part because it was not considered a critical population-level factor. In this paper, we apply the pioneering model- ing ideas of Ross and MacDonald, motivated by the context of the 2000–2001 dengue outbreak in Peru, to assess the dynamics of multi-strain competition. An invading strain of dengue virus (DENV-2) from Asia rapidly circulated into Peru eventually displacing DENV-2 American. A host-dengue model that con- siders the competing dynamics of these two DENV-2 genotypes, the resident or the American type and the invasive more virulent Asian strain, is introduced and analyzed. The model incorporates vertical transmission by DENV-2 Asian a potentially advantageous trait. Conditions for competitive exclusion of dengue strains are established. The model is used to show that lower transmission rates of DENV-2 Asian are sufficient for displacing DENV-2 American in the presence of vertical transmission. |
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