Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K

COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous,...

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Detalhes bibliográficos
Autores: Laiton Donato, Katherine, Usme Ciro, José Aldemar, Franco Muñoz, Carlos, Álvarez Díaz, Diego Alejandro, Ruiz Moreno, Hector A., Reales Gonzalez, Jhonnatan, Prada, Diego A., Corchuelo, Sheryll, Herrera Sepulveda, Maria T., Naizaque, Julián Ricardo, Santamaría, Gerardo, Wiesner, Magdalena, Walteros, Diana Marcela, Ospina Martínez, Martha L., Mercado Reyes, Marcela
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:Colombia
Recursos:Universidad Cooperativa de Colombia
Repositório:Repositorio UCC
OAI Identifier:oai:repository.ucc.edu.co:20.500.12494/45598
Acesso em linha:https://hdl.handle.net/20.500.12494/45598
Access Level:Acceso aberto
Palavra-chave:SARS-CoV-2
Variantes
Evolución
Colombia
Variants
Evolution
Descrição
Resumo:COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage.

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