Novel Highly Divergent SARS-CoV-2 Lineage With the Spike Substitutions L249S and E484K

COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous,...

ver descrição completa

Detalhes bibliográficos
Autores: Laiton-Donato, Katherine, Usme-Ciro, Jose A., Franco-Muñoz, Carlos, Álvarez-Diaz, Diego A., Ruiz-Moreno, Hector A., Reales-Gonzalez, Jhonnatan, Prada, Diego A., Corchuelo, Sheryll, Herrera-Sepulveda, Maria T., Naizaque, Julian, Santamaría, Gerardo, Wiesner, Magdalena, Walteros, Diana M., Ospina-Martínez, Martha L., Mercado-Reyes, Marcela
Formato: artículo
Fecha de publicación:2021
País:Colombia
Recursos:Universidad Cooperativa de Colombia
Repositorio:Repositorio UCC
OAI Identifier:oai:https://repository.ucc.edu.co:20.500.12494/45598
Acesso em linha:https://repository.ucc.edu.co/handle/20.500.12494/45598
Access Level:acceso abierto
Palavra-chave:SARS-CoV-2
Variantes
Evolución
Colombia
Variants
Evolution
Descrição
Resumo:COVID-19 pandemics has led to genetic diversification of SARS-CoV-2 and the appearance of variants with potential impact in transmissibility and viral escape from acquired immunity. We report a new and highly divergent lineage containing 21 distinctive mutations (10 non-synonymous, eight synonymous, and three substitutions in non-coding regions). The amino acid changes L249S and E484K located at the CTD and RBD of the Spike protein could be of special interest due to their potential biological role in the virus-host relationship. Further studies are required for monitoring the epidemiologic impact of this new lineage.

Registos relacionados