Global Respiratory Syncytial Virus-Related Infant Community Deaths

9 páginas

Detalhes bibliográficos
Autores: Mazur N.I, Löwensteyn Y.N, Willemsen J.E, Gill CJ, Forman L., Mwananyanda L.M, Blau DM, Breiman R.F, Madhi S.A, Mahtab S., Gurley E.S
Tipo de documento: artigo
Data de publicação:2021
País:Colombia
Recursos:Universidad de la Sabana
Repositório:Repositorio Universidad de la Sabana
Idioma:inglês
OAI Identifier:oai:intellectum.unisabana.edu.co:10818/53947
Acesso em linha:https://pubmed.ncbi.nlm.nih.gov/34472576/
http://hdl.handle.net/10818/53947
Access Level:Acceso aberto
Palavra-chave:Community death
Lower respiratory tract infection
Respiratory syncytial virus
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spelling Global Respiratory Syncytial Virus-Related Infant Community DeathsMazur N.ILöwensteyn Y.NWillemsen J.EGill CJForman L.Mwananyanda L.MBlau DMBreiman R.FMadhi S.AMahtab S.Gurley E.SCommunity deathLower respiratory tract infectionRespiratory syncytial virus9 páginasBackground: Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in low- and lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods: The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results: We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8-3.3) was lower than in-hospital (2.4 months; IQR: 1.5-4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions: We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.Clin Infect Dis2023-02-16T17:37:28Z2023-02-16T17:37:28Z2021journal articlepublishedVersioninfo:eu-repo/semantics/articleMazur NI, Löwensteyn YN, Willemsen JE, Gill CJ, Forman L, Mwananyanda LM, Blau DM, Breiman RF, Madhi SA, Mahtab S, Gurley ES, El Arifeen S, Assefa N, Scott JAG, Onyango D, Tippet Barr BA, Kotloff KL, Sow SO, Mandomando I, Ogbuanu I, Jambai A, Bassat Q; CHAMPS Network the RSV GOLD Study Group, Caballero MT, Polack FP, Omer S, Kazi AM, Simões EAF, Satav A, Bont LJ. Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S229-S237. doi: 10.1093/cid/ciab528. PMID: 34472576; PMCID: PMC8411255.1537-6591https://pubmed.ncbi.nlm.nih.gov/34472576/http://hdl.handle.net/10818/5394710.1093/cid/ciab528Universidad de La SabanaIntellectum Repositorio Universidad de La Sabanareponame:Repositorio Universidad de la Sabanainstname:Universidad de la Sabanainstacron:Universidad de la SabanaengClin Infect Dis. 2021 Sep 2;73(Suppl_3):S229-S237Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccess2023-02-16T18:02:08Z
dc.title.none.fl_str_mv Global Respiratory Syncytial Virus-Related Infant Community Deaths
title Global Respiratory Syncytial Virus-Related Infant Community Deaths
spellingShingle Global Respiratory Syncytial Virus-Related Infant Community Deaths
Mazur N.I
Community death
Lower respiratory tract infection
Respiratory syncytial virus
title_short Global Respiratory Syncytial Virus-Related Infant Community Deaths
title_full Global Respiratory Syncytial Virus-Related Infant Community Deaths
title_fullStr Global Respiratory Syncytial Virus-Related Infant Community Deaths
title_full_unstemmed Global Respiratory Syncytial Virus-Related Infant Community Deaths
title_sort Global Respiratory Syncytial Virus-Related Infant Community Deaths
dc.creator.none.fl_str_mv Mazur N.I
Löwensteyn Y.N
Willemsen J.E
Gill CJ
Forman L.
Mwananyanda L.M
Blau DM
Breiman R.F
Madhi S.A
Mahtab S.
Gurley E.S
author Mazur N.I
author_facet Mazur N.I
Löwensteyn Y.N
Willemsen J.E
Gill CJ
Forman L.
Mwananyanda L.M
Blau DM
Breiman R.F
Madhi S.A
Mahtab S.
Gurley E.S
author_role author
author2 Löwensteyn Y.N
Willemsen J.E
Gill CJ
Forman L.
Mwananyanda L.M
Blau DM
Breiman R.F
Madhi S.A
Mahtab S.
Gurley E.S
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Community death
Lower respiratory tract infection
Respiratory syncytial virus
topic Community death
Lower respiratory tract infection
Respiratory syncytial virus
description 9 páginas
publishDate 2021
dc.date.none.fl_str_mv 2021
2023-02-16T17:37:28Z
2023-02-16T17:37:28Z
dc.type.none.fl_str_mv journal article
publishedVersion
info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv Mazur NI, Löwensteyn YN, Willemsen JE, Gill CJ, Forman L, Mwananyanda LM, Blau DM, Breiman RF, Madhi SA, Mahtab S, Gurley ES, El Arifeen S, Assefa N, Scott JAG, Onyango D, Tippet Barr BA, Kotloff KL, Sow SO, Mandomando I, Ogbuanu I, Jambai A, Bassat Q; CHAMPS Network the RSV GOLD Study Group, Caballero MT, Polack FP, Omer S, Kazi AM, Simões EAF, Satav A, Bont LJ. Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S229-S237. doi: 10.1093/cid/ciab528. PMID: 34472576; PMCID: PMC8411255.
1537-6591
https://pubmed.ncbi.nlm.nih.gov/34472576/
http://hdl.handle.net/10818/53947
10.1093/cid/ciab528
identifier_str_mv Mazur NI, Löwensteyn YN, Willemsen JE, Gill CJ, Forman L, Mwananyanda LM, Blau DM, Breiman RF, Madhi SA, Mahtab S, Gurley ES, El Arifeen S, Assefa N, Scott JAG, Onyango D, Tippet Barr BA, Kotloff KL, Sow SO, Mandomando I, Ogbuanu I, Jambai A, Bassat Q; CHAMPS Network the RSV GOLD Study Group, Caballero MT, Polack FP, Omer S, Kazi AM, Simões EAF, Satav A, Bont LJ. Global Respiratory Syncytial Virus-Related Infant Community Deaths. Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S229-S237. doi: 10.1093/cid/ciab528. PMID: 34472576; PMCID: PMC8411255.
1537-6591
10.1093/cid/ciab528
url https://pubmed.ncbi.nlm.nih.gov/34472576/
http://hdl.handle.net/10818/53947
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Clin Infect Dis. 2021 Sep 2;73(Suppl_3):S229-S237
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Clin Infect Dis
publisher.none.fl_str_mv Clin Infect Dis
dc.source.none.fl_str_mv Universidad de La Sabana
Intellectum Repositorio Universidad de La Sabana
reponame:Repositorio Universidad de la Sabana
instname:Universidad de la Sabana
instacron:Universidad de la Sabana
instname_str Universidad de la Sabana
instacron_str Universidad de la Sabana
institution Universidad de la Sabana
reponame_str Repositorio Universidad de la Sabana
collection Repositorio Universidad de la Sabana
_version_ 1825050736728211456
score 15,812429

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