Global Respiratory Syncytial Virus-Related Infant Community Deaths

Background. Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in lowand lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain...

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Detalles Bibliográficos
Autores: Mazur, Natalie I., Löwensteyn, Yvette N., Willemsen, Joukje E., Gill, Christopher J., Forman, Leah, Mwananyanda, Lawrence M., Blau, Dianna M., Breiman, Robert F., Madhi, Shabir A., Mahtab, Sana, Gurley, Emily S., El Arifeen, Shams, Assefa, Nega, Scott, J. Anthony G., Onyango, Dickens, Tippet Barr, Beth A., Kotloff, Karen L., Sow, Samba O., Mandomando, Inacio, Ogbuanu, Ikechukwu, Jambai, Amara, Bassat, Quique, Thamthitiwat, Somsak, Gentile, Angela, Lucion, Maria Florencia, Pires, Márcia Rosane, De Paris, Fernanda, Gordon, Aubree, Sánchez, José Félix, Caballero, Mauricio Tomás
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/166810
Acceso en línea:http://hdl.handle.net/11336/166810
Access Level:acceso abierto
Palabra clave:COMMUNITY DEATH
LOWER RESPIRATORY TRACT INFECTION
RESPIRATORY SYNCYTIAL VIRUS
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
Descripción
Sumario:Background. Respiratory syncytial virus (RSV) is a leading cause of pediatric death, with >99% of mortality occurring in lowand lower middle-income countries. At least half of RSV-related deaths are estimated to occur in the community, but clinical characteristics of this group of children remain poorly characterized. Methods. The RSV Global Online Mortality Database (RSV GOLD), a global registry of under-5 children who have died with RSV-related illness, describes clinical characteristics of children dying of RSV through global data sharing. RSV GOLD acts as a collaborative platform for global deaths, including community mortality studies described in this supplement. We aimed to compare the age distribution of infant deaths <6 months occurring in the community with in-hospital. Results. We studied 829 RSV-related deaths <1 year of age from 38 developing countries, including 166 community deaths from 12 countries. There were 629 deaths that occurred <6 months, of which 156 (25%) occurred in the community. Among infants who died before 6 months of age, median age at death in the community (1.5 months; IQR: 0.8−3.3) was lower than in-hospital (2.4 months; IQR: 1.5−4.0; P < .0001). The proportion of neonatal deaths was higher in the community (29%, 46/156) than in-hospital (12%, 57/473, P < 0.0001). Conclusions. We observed that children in the community die at a younger age. We expect that maternal vaccination or immunoprophylaxis against RSV will have a larger impact on RSV-related mortality in the community than in-hospital. This case series of RSV-related community deaths, made possible through global data sharing, allowed us to assess the potential impact of future RSV vaccines.

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