Toxic Epidermal Necrolysis Successfully Treated With Infliximab
Toxic epidermal necrolysis (TEN) is a life-threatening drug-induced cutaneous reaction characterized by widespread apoptosis and detachment of the epidermis. The main causes of death are secondary infections resulting from epidermal damage and multiorgan failure [1]. The severity of illness score (S...
| Authors: | , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2013 |
| Country: | Colombia |
| Institution: | Universidad ICESI |
| Repository: | Repositorio ICESI |
| Language: | English |
| OAI Identifier: | oai:repository.icesi.edu.co:10906/81261 |
| Online Access: | http://nebulosa.icesi.edu.co:2143/full_record.do?product=WOS&search_mode=GeneralSearch&qid=13&SID=2FC4SXeHQQuQBhwxKyC&page=1&doc=2 http://hdl.handle.net/10906/81261 |
| Access Level: | Open access |
| Keyword: | Dermatosis Ciencias socio biomédicas Necrólisis epidérmica tóxica Factor de necrosis tumoral Alergía Medical sciences |
| Summary: | Toxic epidermal necrolysis (TEN) is a life-threatening drug-induced cutaneous reaction characterized by widespread apoptosis and detachment of the epidermis. The main causes of death are secondary infections resulting from epidermal damage and multiorgan failure [1]. The severity of illness score (SCORTEN) [2] analyzes 7 independent risk factors and predicts mortality. Older age, significant comorbidity, and greater skin involvement correlate with a worse prognosis [2]. The pathogenesis of TEN is unknown. Several studies suggest that tumor necrosis factor (TNF) α released from inflammatory cells and activated keratinocytes in the epidermis plays an important role in the immune response by inducing direct cytotoxicity and apoptosis [3]. |
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