Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red

Antecedentes: Liraglutida es un medicamento potencialmente útil en el tratamiento farmacológico de sobrepeso y obesidad, sin embargo, no ha sido evaluada de forma sistemática, ni su relación frente a otras terapias actualmente utilizadas; por lo que el objetivo de este estudio es valorar su eficacia...

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Autores: Sandoval Vásquez, Ricardo Augusto, Suarez Carvajal, Dayana Carolina, Valdivieso Rolleri, María Augusta
Tipo de recurso: tesis de maestría
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:Colombia
Institución:Universidad del Rosario
Repositorio:Repositorio EdocUR - U. Rosario
Idioma:español
OAI Identifier:oai:repository.urosario.edu.co:10336/18879
Acceso en línea:https://doi.org/10.48713/10336_18879
http://repository.urosario.edu.co/handle/10336/18879
Access Level:acceso abierto
Palabra clave:Obesidad
Agentes antiobesidad
Liraglutida
Pérdida de peso
Meta-análisis en red
Enfermedades
Obesity
Anti-obesity agents
Liraglutide
Weight loss
Meta-analysis in the network
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oai_identifier_str oai:repository.urosario.edu.co:10336/18879
network_acronym_str CO
network_name_str Colombia
repository_id_str
dc.title.none.fl_str_mv Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
title Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
spellingShingle Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
Sandoval Vásquez, Ricardo Augusto
Obesidad
Agentes antiobesidad
Liraglutida
Pérdida de peso
Meta-análisis en red
Enfermedades
Obesity
Anti-obesity agents
Liraglutide
Weight loss
Meta-analysis in the network
Obesidad
Liraglutida
title_short Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
title_full Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
title_fullStr Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
title_full_unstemmed Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
title_sort Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en red
dc.creator.none.fl_str_mv Sandoval Vásquez, Ricardo Augusto
Suarez Carvajal, Dayana Carolina
Valdivieso Rolleri, María Augusta
author Sandoval Vásquez, Ricardo Augusto
author_facet Sandoval Vásquez, Ricardo Augusto
Suarez Carvajal, Dayana Carolina
Valdivieso Rolleri, María Augusta
author_role author
author2 Suarez Carvajal, Dayana Carolina
Valdivieso Rolleri, María Augusta
author2_role author
author
dc.subject.none.fl_str_mv Obesidad
Agentes antiobesidad
Liraglutida
Pérdida de peso
Meta-análisis en red
Enfermedades
Obesity
Anti-obesity agents
Liraglutide
Weight loss
Meta-analysis in the network
Obesidad
Liraglutida
topic Obesidad
Agentes antiobesidad
Liraglutida
Pérdida de peso
Meta-análisis en red
Enfermedades
Obesity
Anti-obesity agents
Liraglutide
Weight loss
Meta-analysis in the network
Obesidad
Liraglutida
description Antecedentes: Liraglutida es un medicamento potencialmente útil en el tratamiento farmacológico de sobrepeso y obesidad, sin embargo, no ha sido evaluada de forma sistemática, ni su relación frente a otras terapias actualmente utilizadas; por lo que el objetivo de este estudio es valorar su eficacia comparada contra otros medicamentos, en la reducción de peso corporal. Metodología: Se realizó una revisión sistemática y meta-análisis en red, para la búsqueda se utilizaron las bases de datos Medline, Embase y LiLaCS; se incluyeron ensayos clínicos controlados en inglés y español, concluyendo con un análisis cualitativo y cuantitativo de la información. Resultados: Se incluyeron 20 estudios. De acuerdo al análisis de la comparación directa contra placebo, la liraglutida logró una pérdida de peso de hasta 5 kg en 6 meses (diferencia de promedios -5.28 [-5.49, -5.07]) y contra orlistat, demostró una mayor proporción de pacientes con pérdida del 5% o más del peso corporal (OR 4.02 [2.14, 7.52]). En la comparación indirecta, lorcaserina OR 3,77 (IC95% 3,17 ;4,44) y topiramato/fentermina OR 2,03 (IC95% 1,65; 2,55) mostraron una mayor proporción de pacientes con pérdida de peso del 5% o más. Las reacciones adversas no severas fueron superiores con liraglutida en relación con el resto de terapias farmacológicas exceptuando naltrexona/bupropion. Conclusión: La liraglutida es una opción farmacológica eficaz para el tratamiento de sobrepeso y obesidad. El análisis directo muestra superioridad frente a placebo y orlistat. La comparación indirecta muestra que es inferior a topiramato/fentermina y lorcaserina pero superior a metformina, exenatide, bupropión y naltrexona/bupropion.
publishDate 2018
dc.date.none.fl_str_mv 2018-12-13
2019-01-17T12:41:24Z
dc.type.none.fl_str_mv info:eu-repo/semantics/masterThesis
info:eu-repo/semantics/acceptedVersion
format masterThesis
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.48713/10336_18879
http://repository.urosario.edu.co/handle/10336/18879
url https://doi.org/10.48713/10336_18879
http://repository.urosario.edu.co/handle/10336/18879
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/2.5/co/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/2.5/co/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad del Rosario
Facultad de Medicina
Especialización en Medicina Estética y laser
publisher.none.fl_str_mv Universidad del Rosario
Facultad de Medicina
Especialización en Medicina Estética y laser
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instacron:Universidad del Rosario
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instacron_str Universidad del Rosario
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reponame_str Repositorio EdocUR - U. Rosario
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spelling Eficacia y seguridad de liraglutida para manejo de sobrepeso y obesidad. Revisión sistemática y Metaanálisis en redSandoval Vásquez, Ricardo AugustoSuarez Carvajal, Dayana CarolinaValdivieso Rolleri, María AugustaObesidadAgentes antiobesidadLiraglutidaPérdida de pesoMeta-análisis en redEnfermedadesObesityAnti-obesity agentsLiraglutideWeight lossMeta-analysis in the networkObesidadLiraglutidaAntecedentes: Liraglutida es un medicamento potencialmente útil en el tratamiento farmacológico de sobrepeso y obesidad, sin embargo, no ha sido evaluada de forma sistemática, ni su relación frente a otras terapias actualmente utilizadas; por lo que el objetivo de este estudio es valorar su eficacia comparada contra otros medicamentos, en la reducción de peso corporal. Metodología: Se realizó una revisión sistemática y meta-análisis en red, para la búsqueda se utilizaron las bases de datos Medline, Embase y LiLaCS; se incluyeron ensayos clínicos controlados en inglés y español, concluyendo con un análisis cualitativo y cuantitativo de la información. Resultados: Se incluyeron 20 estudios. De acuerdo al análisis de la comparación directa contra placebo, la liraglutida logró una pérdida de peso de hasta 5 kg en 6 meses (diferencia de promedios -5.28 [-5.49, -5.07]) y contra orlistat, demostró una mayor proporción de pacientes con pérdida del 5% o más del peso corporal (OR 4.02 [2.14, 7.52]). En la comparación indirecta, lorcaserina OR 3,77 (IC95% 3,17 ;4,44) y topiramato/fentermina OR 2,03 (IC95% 1,65; 2,55) mostraron una mayor proporción de pacientes con pérdida de peso del 5% o más. Las reacciones adversas no severas fueron superiores con liraglutida en relación con el resto de terapias farmacológicas exceptuando naltrexona/bupropion. Conclusión: La liraglutida es una opción farmacológica eficaz para el tratamiento de sobrepeso y obesidad. El análisis directo muestra superioridad frente a placebo y orlistat. La comparación indirecta muestra que es inferior a topiramato/fentermina y lorcaserina pero superior a metformina, exenatide, bupropión y naltrexona/bupropion.Background: Liraglutide is a drug that may be useful in the pharmacological treatment of overweight and obesity, however, its effectiveness has not been evaluated systematically or its relationship with other drugs, so the objective of this study is to evaluate its effectiveness in comparison with other currently available management therapies in body weight reduction. Methodology: A systematic review and network meta-analysis were carried out. For the search, Medline, Embase and LiLaCS databases were used and controlled clinical trials published in English and Spanish were included, performing a qualitative and quantitative analysis of the information. Results: Twenty studies were included. According to the analysis of the direct comparison against placebo, Liraglutide achieved a weight loss of up to 5 kg in 6 months (mean difference -5.28 [-5.49, -5.07]) and against Orlistat, showed a higher proportion of patients with loss of 5% or more of body weight (OR 4.02 [2.14, 7.52]). In the indirect comparison, Lorcaserin OR 3.77 (95% CI 3.17, 4.44) and Topiramate / Phentermine OR 2.03 (95% CI 1.65, 2.55) showed a higher proportion of patients with loss of weight of 5% or more. The proportion of non-severe adverse reactions was higher with Liraglutide compared to the rest of the pharmacological therapies except Naltrexone / Bupropion. Conclusion: Liraglutide is an effective pharmacological option for the treatment of overweight/obesity. The direct analysis shows superiority against placebo and Orlistat. 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