Effects of fluids on microvascular perfusion in patients with severe sepsis

Purpose To evaluate the effects of fluid administration on microcirculatory alterations in sepsis. Methods With a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation in 60 patients with severe sepsis. These patients were investigated either within 24 h...

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Detalhes bibliográficos
Autores: Ospina Tascón, Gustavo Adolfo, Backer, Daniel De, Vincent, Jean Louis, Fonseca, Adriana, Oliveira Silva, Tatiana, Chierego, Maria Luisa, Simion, Davide, Büchele, Gustavo, Donadello, Katia, Occhipinti, Giovanna, Neves, Ana Paula
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:Colombia
Recursos:Universidad ICESI
Repositorio:Repositorio ICESI
Idioma:inglés
OAI Identifier:oai:repository.icesi.edu.co:10906/81205
Acesso em linha:http://hdl.handle.net/10906/81205
http://dx.doi.org/10.1007/s00134-010-1843-3
Access Level:acceso abierto
Palavra-chave:Microcirculación
Coloides
Cristaloides y coloides
Sepsis
Descrição
Resumo:Purpose To evaluate the effects of fluid administration on microcirculatory alterations in sepsis. Methods With a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation in 60 patients with severe sepsis. These patients were investigated either within 24 h (early, n = 37) or more than 48 h (late, n = 23) after a diagnosis of severe sepsis. Hemodynamic and microcirculatory measurements were obtained before and 30 min after administration of 1,000 ml Ringer’s lactate (n = 29) or 400 ml 4% albumin (n = 31) solutions.