Effects of fluids on microvascular perfusion in patients with severe sepsis

Purpose To evaluate the effects of fluid administration on microcirculatory alterations in sepsis. Methods With a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation in 60 patients with severe sepsis. These patients were investigated either within 24 h...

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Detalles Bibliográficos
Autores: Ospina Tascón, Gustavo Adolfo, Backer, Daniel De, Vincent, Jean Louis, Fonseca, Adriana, Oliveira Silva, Tatiana, Chierego, Maria Luisa, Simion, Davide, Büchele, Gustavo, Donadello, Katia, Occhipinti, Giovanna, Neves, Ana Paula
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:Colombia
Institución:Universidad ICESI
Repositorio:Repositorio ICESI
Idioma:inglés
OAI Identifier:oai:repository.icesi.edu.co:10906/81205
Acceso en línea:http://hdl.handle.net/10906/81205
http://dx.doi.org/10.1007/s00134-010-1843-3
Access Level:acceso abierto
Palabra clave:Microcirculación
Coloides
Cristaloides y coloides
Sepsis
Descripción
Sumario:Purpose To evaluate the effects of fluid administration on microcirculatory alterations in sepsis. Methods With a Sidestream Dark Field device, we evaluated the effects of fluids on the sublingual microcirculation in 60 patients with severe sepsis. These patients were investigated either within 24 h (early, n = 37) or more than 48 h (late, n = 23) after a diagnosis of severe sepsis. Hemodynamic and microcirculatory measurements were obtained before and 30 min after administration of 1,000 ml Ringer’s lactate (n = 29) or 400 ml 4% albumin (n = 31) solutions.