Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert

A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1AR

Detalles Bibliográficos
Autores: Pessoa-Mahana, Hernan, Silva-Matus, Paul, David Pessoa-Mahana, C, Chung, Hery, Iturriaga-Vasquez, Patricio, Quiroz, Gabriel, Moller-Acuna, Patricia, Zapata-Torres, Gerald, Saitz-Barria, Claudio, Araya-Maturana, Ramiro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/232745
Acceso en línea:https://hdl.handle.net/10533/232745
Access Level:acceso abierto
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spelling Araya-Maturana, RamiroSaitz-Barria, ClaudioZapata-Torres, GeraldMoller-Acuna, PatriciaQuiroz, GabrielIturriaga-Vasquez, PatricioChung, HeryDavid Pessoa-Mahana, CSilva-Matus, PaulPessoa-Mahana, Hernan201710.1002/ardp.201600271https://hdl.handle.net/10533/232745http://purl.org/coar/access_right/c_abf2Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sertPessoa-Mahana, HernanSilva-Matus, PaulDavid Pessoa-Mahana, CChung, HeryIturriaga-Vasquez, PatricioQuiroz, GabrielMoller-Acuna, PatriciaZapata-Torres, GeraldSaitz-Barria, ClaudioAraya-Maturana, Ramiro2018-12-07T13:33:48Z2022-07-07T21:40:54Z20152018-12-07T13:33:48Z2022-07-07T21:40:54Z2017A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1ARRegularFONDECYTFONDECYT11506151150615virtual::42866-1WOS:000396362200002https://hdl.handle.net/10533/232745enghandle/10533/11155710.1002/ardp.201600271handle/10533/111541handle/10533/108045https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.201600271Atribución-NoComercial-SinDerivadas 3.0 Chilehttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/info:eu-repo/semantics/openAccessSynthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sertArchiv Der PharmazieArticuloinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticulohttps://hdl.handle.net/10533/232745FONDECYThttp://purl.org/coar/resource_type/c_2df8fbb178c5c6a5-95d4-45ba-84ba-fb89d3deeb35virtual::42866-178c5c6a5-95d4-45ba-84ba-fb89d3deeb35virtual::42866-110533/232745oai:repositorio.anid.cl:10533/2327452023-07-24 17:30:19.297https://repositorio.anid.clRepositorio ANIDaletelier@anid.cl
dc.title.none.fl_str_mv Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
dc.title.journal.none.fl_str_mv Archiv Der Pharmazie
title Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
spellingShingle Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
Pessoa-Mahana, Hernan
title_short Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
title_full Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
title_fullStr Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
title_full_unstemmed Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
title_sort Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert
dc.creator.none.fl_str_mv Pessoa-Mahana, Hernan
Silva-Matus, Paul
David Pessoa-Mahana, C
Chung, Hery
Iturriaga-Vasquez, Patricio
Quiroz, Gabriel
Moller-Acuna, Patricia
Zapata-Torres, Gerald
Saitz-Barria, Claudio
Araya-Maturana, Ramiro
author Pessoa-Mahana, Hernan
author_facet Pessoa-Mahana, Hernan
Silva-Matus, Paul
David Pessoa-Mahana, C
Chung, Hery
Iturriaga-Vasquez, Patricio
Quiroz, Gabriel
Moller-Acuna, Patricia
Zapata-Torres, Gerald
Saitz-Barria, Claudio
Araya-Maturana, Ramiro
author_role author
author2 Silva-Matus, Paul
David Pessoa-Mahana, C
Chung, Hery
Iturriaga-Vasquez, Patricio
Quiroz, Gabriel
Moller-Acuna, Patricia
Zapata-Torres, Gerald
Saitz-Barria, Claudio
Araya-Maturana, Ramiro
author2_role author
author
author
author
author
author
author
author
author
description A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1AR
publishDate 2015
dc.date.annoconcurso.none.fl_str_mv 2015
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2018-12-07T13:33:48Z
2022-07-07T21:40:54Z
dc.date.available.none.fl_str_mv 2018-12-07T13:33:48Z
2022-07-07T21:40:54Z
dc.type.none.fl_str_mv Articulo
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.openaire.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.folio.none.fl_str_mv 1150615
1150615
dc.identifier.idwos.none.fl_str_mv WOS:000396362200002
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/10533/232745
identifier_str_mv 1150615
WOS:000396362200002
url https://hdl.handle.net/10533/232745
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.contest.none.fl_str_mv handle/10533/111557
dc.relation.doi.none.fl_str_mv 10.1002/ardp.201600271
dc.relation.instrument.none.fl_str_mv handle/10533/111541
dc.relation.program.none.fl_str_mv handle/10533/108045
dc.relation.uri.none.fl_str_mv https://onlinelibrary.wiley.com/doi/full/10.1002/ardp.201600271
dc.rights.none.fl_str_mv Atribución-NoComercial-SinDerivadas 3.0 Chile
http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rights.driver.none.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv Atribución-NoComercial-SinDerivadas 3.0 Chile
http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
eu_rights_str_mv openAccess
repository.name.fl_str_mv Repositorio ANID
repository.mail.fl_str_mv aletelier@anid.cl
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score 15.811543

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