Synthesis and docking of novel 3-indolylpropyl derivatives as new polypharmacological agents displaying affinity for 5-ht1ar/sert

A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1AR

Detalles Bibliográficos
Autores: Pessoa-Mahana, Hernan, Silva-Matus, Paul, David Pessoa-Mahana, C, Chung, Hery, Iturriaga-Vasquez, Patricio, Quiroz, Gabriel, Moller-Acuna, Patricia, Zapata-Torres, Gerald, Saitz-Barria, Claudio, Araya-Maturana, Ramiro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/232745
Acceso en línea:https://hdl.handle.net/10533/232745
Access Level:acceso abierto
Descripción
Sumario:A series of novel 3-indolylpropyl derivatives was synthesized and evaluated for their binding affinities at the serotonin-1A receptor subtype (5-HT1AR) and the 5-HT transporter (SERT). Compounds 11b and 14b exhibited the highest affinities at the 5-HT1AR