A feed-forward mechanism involving the nox complex and ryr-mediated ca2+release during axonal specification

Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shape neurons remain unknown. Ca2+, a broad intracellular second messenger, promotes both Rac1 activation and neurite extension. C

Detalhes bibliográficos
Autores: Wilson, Carlos, Muñoz-Palma, Ernesto, Henríquez, Daniel R, Palmisano, Ilaria, Nuñez, Marco Tulio, Di Giovanni, Simone, González-Billault, Christian Enrique
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/227992
Acesso em linha:https://hdl.handle.net/10533/227992
Access Level:acceso abierto
Descrição
Resumo:Physiological levels of ROS support neurite outgrowth and axonal specification, but the mechanisms by which ROS are able to shape neurons remain unknown. Ca2+, a broad intracellular second messenger, promotes both Rac1 activation and neurite extension. C