The syndromic deafness mutation g12r impairs fast and slow gating in cx26 hemichannels

Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical

Detalles Bibliográficos
Autores: Garcia, Isaac E, Villanelo, Felipe, Contreras, Gustavo F, Pupo, Amaury, Pinto, Bernardo, I, Contreras, Jorge E, Perez-Acle, Tomas, Alvarez, Osvaldo, Latorre, Ramon, Martinez, Agustin D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/231949
Acceso en línea:https://hdl.handle.net/10533/231949
Access Level:acceso abierto
Descripción
Sumario:Mutations in connexin 26 (Cx26) hemichannels can lead to syndromic deafness that affects the cochlea and skin. These mutations lead to gain-of-function hemichannel phenotypes by unknown molecular mechanisms. In this study, we investigate the biophysical