Role of the cys loop and transmembrane domain in the allosteric modulation of alpha 4 beta 2 nicotinic acetylcholine receptors

Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel gating. Using alpha 4 beta 2 nicotinic acetylcholine receptors and the alpha 4 beta 2-selective positive mo

Detalles Bibliográficos
Autores: Alcaino, Constanza, Musgaard, Maria, Minguez, Teresa, Mazzaferro, Simone, Faundez, Manuel, Iturriaga-Vasquez, Patricio, Biggin, Philip C, Bermudez, Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:Chile
Idioma:inglés
OAI Identifier:oai:repositorio.anid.cl:10533/232747
Acceso en línea:https://hdl.handle.net/10533/232747
Access Level:acceso abierto
Descripción
Sumario:Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements of the pathways that couple agonist binding to channel gating. Using alpha 4 beta 2 nicotinic acetylcholine receptors and the alpha 4 beta 2-selective positive mo