Integrative review: verification of efficacy / effectiveness of medical Cannabis and cannabinoid derivatives in Alzheimer´s disease
Considering the limited therapeutic effects of current medications for trying to treat or reduce the symptoms of Alzheimer's disease, it is relevant to search for new therapeutic alternatives, with significant efficacy and reduced side effects. One of the promising solutions to prevent the prog...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | Brasil |
| Institución: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repositorio: | Revista Fitos |
| Idioma: | portugués |
| OAI Identifier: | oai:ojs.revistafitos.far.fiocruz.br:article/1255 |
| Acceso en línea: | https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1255 |
| Access Level: | acceso abierto |
| Palabra clave: | Doença de Alzheimer Canabinoide Cannabis sativa Demência Alzheimer disease Cannabinoids Dementia |
| Sumario: | Considering the limited therapeutic effects of current medications for trying to treat or reduce the symptoms of Alzheimer's disease, it is relevant to search for new therapeutic alternatives, with significant efficacy and reduced side effects. One of the promising solutions to prevent the progression of behavioral and cognitive changes in the disease are cannabinoid derivatives, in which in vivo studies have shown a reduction in oxidative stress, neuroinflammation, formation of amyloid plaques and neurofibrillary tangles, in addition being related to regulation activation of microglial cells and release of macromolecules, all factors that, when present, contribute to the worsening and evolution of the disease. Medicinal Cannabis and cannabinoid derivatives such as cannabidiol and Δ9-tetrahydrocannabinol have shown very significant therapeutic efficacy for various diseases and symptoms, such as chronic pain, nausea and vomiting induced by chemotherapy, multiple sclerosis, anorexia nervosa, anxiety, Huntington's disease, Parkinson's disease, epilepsy, Alzheimer's disease, among others. Therefore, this work aimed to gather studies that would enable the analysis of the efficacy/effectiveness of cannabinoid derivatives in Alzheimer's disease in more updated publications. |
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