Mixed mammary carcinoma in a guinea pig (Cavia porcellus)
Background: Thirteen mammary neoplasms types are described in Cavia porcellus in the literature. Among these, the most prevalent are the benign and spontaneous neoplasms (70%), between the malignant stand out the adenocarcinomas (majoritary), tubular and tubulopapillary, however, when it comes to mi...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2023 |
| País: | Brasil |
| Institución: | Universidade Federal do Rio Grande do Sul (UFRGS) |
| Repositorio: | Revista Acta Scientiae Veterinariae (Online) |
| Idioma: | inglés |
| OAI Identifier: | oai:seer.ufrgs.br:article/130962 |
| Acceso en línea: | https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/130962 |
| Access Level: | acceso abierto |
| Palabra clave: | mammary carcinoma, mammary gland, neoplasm, guinea pig. carcinoma mamário, glândula mamária, neoplasia, porquinho-da-índia. |
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Mixed mammary carcinoma in a guinea pig (Cavia porcellus) Carcinoma mamário misto em porquinho-da-Índia (Cavia porcellus) |
| title |
Mixed mammary carcinoma in a guinea pig (Cavia porcellus) |
| spellingShingle |
Mixed mammary carcinoma in a guinea pig (Cavia porcellus) Martinez-Pereira, Malcon mammary carcinoma, mammary gland, neoplasm, guinea pig. carcinoma mamário, glândula mamária, neoplasia, porquinho-da-índia. |
| title_short |
Mixed mammary carcinoma in a guinea pig (Cavia porcellus) |
| title_full |
Mixed mammary carcinoma in a guinea pig (Cavia porcellus) |
| title_fullStr |
Mixed mammary carcinoma in a guinea pig (Cavia porcellus) |
| title_full_unstemmed |
Mixed mammary carcinoma in a guinea pig (Cavia porcellus) |
| title_sort |
Mixed mammary carcinoma in a guinea pig (Cavia porcellus) |
| dc.creator.none.fl_str_mv |
Martinez-Pereira, Malcon Alcântara Gomes, Paulo Henrique Pereira, Lucas de Paula Berri, Alessandra Nelcir Padilha, Vanessa Sasso Veiga, Angela Patricia Medeiros Baron, Aline Ruediger Ramos, Adriano Tony |
| author |
Martinez-Pereira, Malcon |
| author_facet |
Martinez-Pereira, Malcon Alcântara Gomes, Paulo Henrique Pereira, Lucas de Paula Berri, Alessandra Nelcir Padilha, Vanessa Sasso Veiga, Angela Patricia Medeiros Baron, Aline Ruediger Ramos, Adriano Tony |
| author_role |
author |
| author2 |
Alcântara Gomes, Paulo Henrique Pereira, Lucas de Paula Berri, Alessandra Nelcir Padilha, Vanessa Sasso Veiga, Angela Patricia Medeiros Baron, Aline Ruediger Ramos, Adriano Tony |
| author2_role |
author author author author author author author |
| dc.subject.por.fl_str_mv |
mammary carcinoma, mammary gland, neoplasm, guinea pig. carcinoma mamário, glândula mamária, neoplasia, porquinho-da-índia. |
| topic |
mammary carcinoma, mammary gland, neoplasm, guinea pig. carcinoma mamário, glândula mamária, neoplasia, porquinho-da-índia. |
| description |
Background: Thirteen mammary neoplasms types are described in Cavia porcellus in the literature. Among these, the most prevalent are the benign and spontaneous neoplasms (70%), between the malignant stand out the adenocarcinomas (majoritary), tubular and tubulopapillary, however, when it comes to mixed carcinomas, despite being rare, they present greater malignancy. The present study aims to report the case of a guinea pig cytologic and histologically diagnosed with mammary gland mixed carcinoma treated by surgical excision. Case: A 1-year-old female Abyssinian guinea pig weighing 1.1 kg was treated at the Wild and Exotic Animal Sector of the Federal University of Santa Catarina (UFSC)in the city of Curitibanos, SC, Brazil. The patient revealed an alert and docile temperament without considerable physiological changes in the physical examination. The patient presented a mass, measuring 1.4 x 1.6 cm with a nodular appearance, firm consistency and not adhered in the region of the left inguinal mammary gland. A sample was collected by fine needle aspiration biopsy technique (FNAB), which revealed to be suggestive of malignant neoplasm from epithelial tissue, due observation of presence of 3-dimensional clusters of epithelial cells, with discrete anisocytosis and anisokaryosis. In 7 days, the nodule showed gradual and progressive growth, measuring 2.0 x 1.6 cm. Radiographs were taken in order to rule out the presence of metastases in other organs and systems. The suitable treatment was surgical excision of the nodule and mammary gland, which occurred without intercurrences, and the material was sent for histopathological analysis. On the day of the surgical procedure, the nodule measured 2.4 x 1.6 cm. As a result, it was noted the rupture of tubules, isolated cells or forming nests in the middle of the stroma composed mainly of myoepithelial cells and adipocytes and presence of lymphoplasmacytic and neutrophilic infiltrate, compatible with mixed mammary gland carcinoma in a grade I. After 10 days of the procedure, the patient was released healthy and weighing 1.18 kg. Due to the absence of metastasis was not indicated post-surgical chemotherapy, however it was proposed ovariohysterectomy in order to prevent recurrence. So far, there has been no sign of recurrence or development of metastases in the patient. Discussion: In fact, guinea pig mammary neoplasms are locally invasive, large in size and highly vascularized, but they rarely metastasize, and there is no sexual predisposition. An important characteristic of the guinea pigs neoplasms is the fast growth that can be associated with the accelerated metabolism in these animals. Diagnostic methods such as FNAB are important to differentiate non-neoplastic from neoplastic processes, as mastitis or mammary hyperplasia. However, the cytologic appearance may vary greatly depending on the type of neoplasm, thus the histopathology provides the definitive diagnosis. Surgical excision is the treatment of choice, once these animals are poorly tolerant to chemotherapy. The adoption of measures, as ovariohysterectomy, can help the treatment or prevention of mammary neoplasms, although the tutor refutes the indication in this case. On the other hand, there is a still gap in the knowledge of neoplasms in guinea pig, making studies allow us to understand the pathophysiology of these diseases in this specie. Keywords: mammary carcinoma, mammary gland, neoplasm, guinea pig. Título: Carcinoma mamário misto em porquinho-da-Índia (Cavia porcellus) Descritores: carcinoma mamário, glândula mamária, neoplasia, porquinho-da-índia. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-10-31 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/130962 10.22456/1679-9216.130962 |
| url |
https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/130962 |
| identifier_str_mv |
10.22456/1679-9216.130962 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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https://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/130962/90239 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Universidade Federal do Rio Grande do Sul |
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Universidade Federal do Rio Grande do Sul |
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Acta Scientiae Veterinariae; Vol. 51 (2023): CASE REPORTS (SUPPLEMENT) Acta Scientiae Veterinariae; v. 51 (2023): CASE REPORTS (SUPPLEMENT) 1679-9216 reponame:Revista Acta Scientiae Veterinariae (Online) instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
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Revista Acta Scientiae Veterinariae (Online) |
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Revista Acta Scientiae Veterinariae (Online) |
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Revista Acta Scientiae Veterinariae (Online) - Universidade Federal do Rio Grande do Sul (UFRGS) |
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questions-acta@ufrgs.br |
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1853663662462468096 |
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Mixed mammary carcinoma in a guinea pig (Cavia porcellus) Carcinoma mamário misto em porquinho-da-Índia (Cavia porcellus)mammary carcinoma, mammary gland, neoplasm, guinea pig.carcinoma mamário, glândula mamária, neoplasia, porquinho-da-índia.Background: Thirteen mammary neoplasms types are described in Cavia porcellus in the literature. Among these, the most prevalent are the benign and spontaneous neoplasms (70%), between the malignant stand out the adenocarcinomas (majoritary), tubular and tubulopapillary, however, when it comes to mixed carcinomas, despite being rare, they present greater malignancy. The present study aims to report the case of a guinea pig cytologic and histologically diagnosed with mammary gland mixed carcinoma treated by surgical excision. Case: A 1-year-old female Abyssinian guinea pig weighing 1.1 kg was treated at the Wild and Exotic Animal Sector of the Federal University of Santa Catarina (UFSC)in the city of Curitibanos, SC, Brazil. The patient revealed an alert and docile temperament without considerable physiological changes in the physical examination. The patient presented a mass, measuring 1.4 x 1.6 cm with a nodular appearance, firm consistency and not adhered in the region of the left inguinal mammary gland. A sample was collected by fine needle aspiration biopsy technique (FNAB), which revealed to be suggestive of malignant neoplasm from epithelial tissue, due observation of presence of 3-dimensional clusters of epithelial cells, with discrete anisocytosis and anisokaryosis. In 7 days, the nodule showed gradual and progressive growth, measuring 2.0 x 1.6 cm. Radiographs were taken in order to rule out the presence of metastases in other organs and systems. The suitable treatment was surgical excision of the nodule and mammary gland, which occurred without intercurrences, and the material was sent for histopathological analysis. On the day of the surgical procedure, the nodule measured 2.4 x 1.6 cm. As a result, it was noted the rupture of tubules, isolated cells or forming nests in the middle of the stroma composed mainly of myoepithelial cells and adipocytes and presence of lymphoplasmacytic and neutrophilic infiltrate, compatible with mixed mammary gland carcinoma in a grade I. After 10 days of the procedure, the patient was released healthy and weighing 1.18 kg. Due to the absence of metastasis was not indicated post-surgical chemotherapy, however it was proposed ovariohysterectomy in order to prevent recurrence. So far, there has been no sign of recurrence or development of metastases in the patient. Discussion: In fact, guinea pig mammary neoplasms are locally invasive, large in size and highly vascularized, but they rarely metastasize, and there is no sexual predisposition. An important characteristic of the guinea pigs neoplasms is the fast growth that can be associated with the accelerated metabolism in these animals. Diagnostic methods such as FNAB are important to differentiate non-neoplastic from neoplastic processes, as mastitis or mammary hyperplasia. However, the cytologic appearance may vary greatly depending on the type of neoplasm, thus the histopathology provides the definitive diagnosis. Surgical excision is the treatment of choice, once these animals are poorly tolerant to chemotherapy. The adoption of measures, as ovariohysterectomy, can help the treatment or prevention of mammary neoplasms, although the tutor refutes the indication in this case. On the other hand, there is a still gap in the knowledge of neoplasms in guinea pig, making studies allow us to understand the pathophysiology of these diseases in this specie. Keywords: mammary carcinoma, mammary gland, neoplasm, guinea pig. Título: Carcinoma mamário misto em porquinho-da-Índia (Cavia porcellus) Descritores: carcinoma mamário, glândula mamária, neoplasia, porquinho-da-índia.Introdução: Treze tipos de neoplasias mamárias são descritos na literatura em Cavia porcellus. Dentre estes, os mais prevalentes são as neoplasias benignas e espontâneas (70%), entre os malignos destacam-se os adenocarcinomas (majoritários), tubulares e tubulopapilares, porém, quando se trata de carcinomas mistos, apesar de raros, apresentam maior malignidade. O presente estudo tem como objetivo relatar o caso de um porquinho da índia (PDI) com diagnóstico citológico e histológico de carcinoma misto de glândula mamária tratado por excisão cirúrgica. Caso: Foi atendida no setor de animais silvestres e exóticos da Universidade Federal de Santa Catarina na cidade de Curitibanos, Santa Catarina, Brasil, um PDI Abissínio, fêmea, com 1 ano de idade, pesando 1,1 kg. A paciente revelou temperamento alerta e dócil, sem alterações fisiológicas consideráveis ao exame físico. A paciente apresentava massa medindo 1,4 x 1,6 cm de aspecto nodular, consistência firme e não aderida em região de glândula mamária inguinal esquerda. Foi coletada amostra pela técnica de punção aspirativa com agulha fina (PAAF), que se revelou sugestiva de neoplasia maligna de tecido epitelial, pela observação da presença de aglomerados tridimensionais de células epiteliais, com discreta anisocitose e anisocariose. Em sete dias, o nódulo apresentou crescimento gradual e progressivo, medindo 2,0 x 1,6 cm. Radiografias foram realizadas para descartar a presença de metástases em outros órgãos e sistemas. O tratamento indicado foi a excisão cirúrgica do nódulo e da glândula mamária, que ocorreu sem intercorrências, sendo o material enviado para análise histopatológica. No dia do procedimento cirúrgico, o nódulo media 2,4 x 1,6 cm. Como resultado, notou-se ruptura de túbulos, células isoladas ou formando ninhos no meio do estroma composto principalmente por células mioepiteliais e adipócitos e presença de infiltrado linfoplasmocítico e neutrofílico, compatível com carcinoma misto de glândula mamária grau I. Após 10 dias do procedimento, a paciente apresentou-se hígida e pesando 1,18 kg, recebendo alta médica. Devido à ausência de metástase não foi indicada quimioterapia pós-cirúrgica, porém foi proposta a ovariohisterectomia a fim de prevenir a recidiva. Não houve nenhum sinal de recorrência ou desenvolvimento de metástases no paciente, até o momento. Discussão: De fato, as neoplasias mamárias em PDI são localmente invasivas, grandes e altamente vascularizadas, mas raramente metastatizam e não há predisposição sexual. Uma característica importante das neoplasias PDI é o crescimento rápido que pode estar associado ao metabolismo acelerado desses animais. Métodos diagnósticos como PAAF são importantes para diferenciar processos não neoplásicos de neoplásicos, como mastite ou hiperplasia mamária. No entanto, o aspecto citológico pode variar muito dependendo do tipo de neoplasia, portanto a histopatologia fornece o diagnóstico definitivo. A excisão cirúrgica é o tratamento de escolha, uma vez que esses animais são pouco tolerantes à quimioterapia. A adoção de medidas, como a ovariohisterectomia, pode auxiliar no tratamento ou prevenção de neoplasias mamárias, embora o tutor tenha refutado a indicação neste caso. Por outro lado, ainda existe uma lacuna no conhecimento das neoplasias em cobaias, fazendo com que estudos nos permitam entender a fisiopatologia dessas doenças nessa espécie.Universidade Federal do Rio Grande do Sul2023-10-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/13096210.22456/1679-9216.130962Acta Scientiae Veterinariae; Vol. 51 (2023): CASE REPORTS (SUPPLEMENT)Acta Scientiae Veterinariae; v. 51 (2023): CASE REPORTS (SUPPLEMENT)1679-9216reponame:Revista Acta Scientiae Veterinariae (Online)instname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSenghttps://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/article/view/130962/90239Copyright (c) 2023 Malcon Martinez-Pereira, Paulo Henrique Alcântara Gomes, Lucas de Paula Pereira, Alessandra Nelcir Berri, Vanessa Sasso Padilha, Angela Patricia Medeiros Veiga, Aline Ruediger Baron, Adriano Tony Ramosinfo:eu-repo/semantics/openAccessMartinez-Pereira, MalconAlcântara Gomes, Paulo HenriquePereira, Lucas de PaulaBerri, Alessandra NelcirPadilha, Vanessa SassoVeiga, Angela Patricia MedeirosBaron, Aline RuedigerRamos, Adriano Tony2024-12-23T17:08:40Zoai:seer.ufrgs.br:article/130962Revistahttps://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/oaiPUBhttps://seer.ufrgs.br/index.php/ActaScientiaeVeterinariae/indexquestions-acta@ufrgs.br1679-92161678-0345opendoar:2024-12-23T17:08:40Revista Acta Scientiae Veterinariae (Online) - Universidade Federal do Rio Grande do Sul (UFRGS)false |
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