Cyclooxigenase-2 expression in primary metastatic and non metastatic canine mammarian carcinomas
The aim of this study was to detect the expression of ciclooxigenase-2 (COX-2) in metastatic primary carcinoma and non metastatic carcinoma, taking into consideration the relation between COX-2 and the progression of cancer. Evaluation of the COX-2 expression was achieved by immunohistochemistry ana...
| Autores: | , , , , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 2013 |
| País: | Brasil |
| Recursos: | Universidade Estadual Paulista (UNESP) |
| Repositório: | Repositório Institucional da UNESP |
| Idioma: | espanhol |
| OAI Identifier: | oai:repositorio.unesp.br:11449/111230 |
| Acesso em linha: | http://dx.doi.org/10.4067/S0301-732X2013000300012 http://hdl.handle.net/11449/111230 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cancer Mammary neoplasm ciclooxigenase-2 Dog |
| Resumo: | The aim of this study was to detect the expression of ciclooxigenase-2 (COX-2) in metastatic primary carcinoma and non metastatic carcinoma, taking into consideration the relation between COX-2 and the progression of cancer. Evaluation of the COX-2 expression was achieved by immunohistochemistry analysis, using the primary polyclonal antibody anti-PGHS-2, clone PG 27, (Oxford Biomedical Research). The number of marked cells by the COX-2 antibody was higher (P < 0.001) in the metastatic primary carcinoma (81.25%) than non-metastatic (60.3%). There was a positive correlation between the number of labeled cells. |
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