Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats

OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fruc...

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Autores: Mostarda, Cristiano, Moraes-Silva, Ivana Cinthya, Salemi, Vera Maria Cury, Machi, Jacqueline Freire, Rodrigues, Bruno, De Angelis, Kátia, Farah, Vera de Moura Azevedo, Irigoyen, Maria Claudia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:Brasil
Institución:Universidade de São Paulo (USP)
Repositorio:Clinics
Idioma:inglés
OAI Identifier:oai:revistas.usp.br:article/40159
Acceso en línea:https://www.revistas.usp.br/clinics/article/view/40159
Access Level:acceso abierto
Palabra clave:Metabolic Syndrome
Diastolic function
Exercise Training
Insulin resistance
Cardiac hypertrophy
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spelling Exercise training prevents diastolic dysfunction induced by metabolic syndrome in ratsMetabolic SyndromeDiastolic functionExercise TrainingInsulin resistanceCardiac hypertrophyOBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at pHospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo2012-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://www.revistas.usp.br/clinics/article/view/4015910.6061/clinics/2012(07)18Clinics; Vol. 67 No. 7 (2012); 815-820Clinics; v. 67 n. 7 (2012); 815-820Clinics; Vol. 67 Núm. 7 (2012); 815-8201980-53221807-5932reponame:Clinicsinstname:Universidade de São Paulo (USP)instacron:USPenghttps://www.revistas.usp.br/clinics/article/view/40159/43025info:eu-repo/semantics/openAccessMostarda, CristianoMoraes-Silva, Ivana CinthyaSalemi, Vera Maria CuryMachi, Jacqueline FreireRodrigues, BrunoDe Angelis, KátiaFarah, Vera de Moura AzevedoIrigoyen, Maria Claudia2012-08-23T18:32:22Zoai:revistas.usp.br:article/40159Revistahttps://www.revistas.usp.br/clinicsPUBhttps://www.revistas.usp.br/clinics/oai||clinics@hc.fm.usp.br1980-53221807-5932opendoar:2012-08-23T18:32:22Clinics - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
title Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
spellingShingle Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
Mostarda, Cristiano
Metabolic Syndrome
Diastolic function
Exercise Training
Insulin resistance
Cardiac hypertrophy
title_short Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
title_full Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
title_fullStr Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
title_full_unstemmed Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
title_sort Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
dc.creator.none.fl_str_mv Mostarda, Cristiano
Moraes-Silva, Ivana Cinthya
Salemi, Vera Maria Cury
Machi, Jacqueline Freire
Rodrigues, Bruno
De Angelis, Kátia
Farah, Vera de Moura Azevedo
Irigoyen, Maria Claudia
author Mostarda, Cristiano
author_facet Mostarda, Cristiano
Moraes-Silva, Ivana Cinthya
Salemi, Vera Maria Cury
Machi, Jacqueline Freire
Rodrigues, Bruno
De Angelis, Kátia
Farah, Vera de Moura Azevedo
Irigoyen, Maria Claudia
author_role author
author2 Moraes-Silva, Ivana Cinthya
Salemi, Vera Maria Cury
Machi, Jacqueline Freire
Rodrigues, Bruno
De Angelis, Kátia
Farah, Vera de Moura Azevedo
Irigoyen, Maria Claudia
author2_role author
author
author
author
author
author
author
dc.subject.por.fl_str_mv Metabolic Syndrome
Diastolic function
Exercise Training
Insulin resistance
Cardiac hypertrophy
topic Metabolic Syndrome
Diastolic function
Exercise Training
Insulin resistance
Cardiac hypertrophy
description OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p
publishDate 2012
dc.date.none.fl_str_mv 2012-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://www.revistas.usp.br/clinics/article/view/40159
10.6061/clinics/2012(07)18
url https://www.revistas.usp.br/clinics/article/view/40159
identifier_str_mv 10.6061/clinics/2012(07)18
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://www.revistas.usp.br/clinics/article/view/40159/43025
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
publisher.none.fl_str_mv Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
dc.source.none.fl_str_mv Clinics; Vol. 67 No. 7 (2012); 815-820
Clinics; v. 67 n. 7 (2012); 815-820
Clinics; Vol. 67 Núm. 7 (2012); 815-820
1980-5322
1807-5932
reponame:Clinics
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Clinics
collection Clinics
repository.name.fl_str_mv Clinics - Universidade de São Paulo (USP)
repository.mail.fl_str_mv ||clinics@hc.fm.usp.br
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score 15.301603

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