Exercise training prevents diastolic dysfunction induced by metabolic syndrome in rats
OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fruc...
| Authors: | , , , , , , , |
|---|---|
| Format: | article |
| Status: | Published version |
| Publication Date: | 2012 |
| Country: | Brasil |
| Institution: | Universidade de São Paulo (USP) |
| Repository: | Clinics |
| Language: | English |
| OAI Identifier: | oai:revistas.usp.br:article/40159 |
| Online Access: | https://www.revistas.usp.br/clinics/article/view/40159 |
| Access Level: | Open access |
| Keyword: | Metabolic Syndrome Diastolic function Exercise Training Insulin resistance Cardiac hypertrophy |
| Summary: | OBJECTIVE: High fructose consumption contributes to the incidence of metabolic syndrome and, consequently, to cardiovascular outcomes. We investigated whether exercise training prevents high fructose diet-induced metabolic and cardiac morphofunctional alterations. METHODS: Wistar rats receiving fructose overload (F) in drinking water (100 g/l) were concomitantly trained on a treadmill (FT) for 10 weeks or kept sedentary. These rats were compared with a control group (C). Obesity was evaluated by the Lee index, and glycemia and insulin tolerance tests constituted the metabolic evaluation. Blood pressure was measured directly (Windaq, 2 kHz), and echocardiography was performed to determine left ventricular morphology and function. Statistical significance was determined by one-way ANOVA, with significance set at p |
|---|