Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to...

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Autores: Espíndola, Otávio Melo, Brandão, Carlos Otávio, Gomes, Yago Côrtes Pinheiro, Siqueira, Marilda Agudo Mendonça Teixeira de, Soares, Cristiane Nascimento, Lima, Marco Antônio Sales Dantas, Leite, Ana Claudia Celestino Bezerra, Torezani, Guilherme, Araujo, Abelardo Queiroz Campos, Silva, Marcus Tulius Teixeira
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:Brasil
Institución:Fundação Oswaldo Cruz (FIOCRUZ)
Repositorio:Repositório Institucional da FIOCRUZ (ARCA)
Idioma:inglés
OAI Identifier:oai:arca.fiocruz.br:icict/44311
Acceso en línea:https://arca.fiocruz.br/handle/icict/44311
Access Level:acceso abierto
Palabra clave:COVID-19
SARS-CoV-2
Cerebrospinal fluid
Neurofilament light protein
Total Tau protein
Oligoclonal bands
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dc.title.none.fl_str_mv Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
title Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
spellingShingle Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
Espíndola, Otávio Melo
COVID-19
SARS-CoV-2
Cerebrospinal fluid
Neurofilament light protein
Total Tau protein
Oligoclonal bands
title_short Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
title_full Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
title_fullStr Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
title_full_unstemmed Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
title_sort Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)
dc.creator.none.fl_str_mv Espíndola, Otávio Melo
Brandão, Carlos Otávio
Gomes, Yago Côrtes Pinheiro
Siqueira, Marilda Agudo Mendonça Teixeira de
Soares, Cristiane Nascimento
Lima, Marco Antônio Sales Dantas
Leite, Ana Claudia Celestino Bezerra
Torezani, Guilherme
Araujo, Abelardo Queiroz Campos
Silva, Marcus Tulius Teixeira
author Espíndola, Otávio Melo
author_facet Espíndola, Otávio Melo
Brandão, Carlos Otávio
Gomes, Yago Côrtes Pinheiro
Siqueira, Marilda Agudo Mendonça Teixeira de
Soares, Cristiane Nascimento
Lima, Marco Antônio Sales Dantas
Leite, Ana Claudia Celestino Bezerra
Torezani, Guilherme
Araujo, Abelardo Queiroz Campos
Silva, Marcus Tulius Teixeira
author_role author
author2 Brandão, Carlos Otávio
Gomes, Yago Côrtes Pinheiro
Siqueira, Marilda Agudo Mendonça Teixeira de
Soares, Cristiane Nascimento
Lima, Marco Antônio Sales Dantas
Leite, Ana Claudia Celestino Bezerra
Torezani, Guilherme
Araujo, Abelardo Queiroz Campos
Silva, Marcus Tulius Teixeira
author2_role author
author
author
author
author
author
author
author
author
dc.subject.en.none.fl_str_mv COVID-19
SARS-CoV-2
Cerebrospinal fluid
Neurofilament light protein
Total Tau protein
Oligoclonal bands
topic COVID-19
SARS-CoV-2
Cerebrospinal fluid
Neurofilament light protein
Total Tau protein
Oligoclonal bands
description Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-11-04T22:28:40Z
dc.date.available.fl_str_mv 2020-11-04T22:28:40Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ESPÍNDOLA, Otavio Melo et al. Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development. International Journal of Infectious Diseases, p. 1-23, 2020.
dc.identifier.uri.fl_str_mv https://arca.fiocruz.br/handle/icict/44311
dc.identifier.issn.none.fl_str_mv 1201-9712
dc.identifier.doi.none.fl_str_mv 10.1016/j.ijid.2020.10.044
identifier_str_mv ESPÍNDOLA, Otavio Melo et al. Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development. International Journal of Infectious Diseases, p. 1-23, 2020.
1201-9712
10.1016/j.ijid.2020.10.044
url https://arca.fiocruz.br/handle/icict/44311
dc.language.iso.fl_str_mv eng
language eng
dc.relation.hasversion.none.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51150
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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spelling 2020-11-04T22:28:40Z2020-11-04T22:28:40Z2020ESPÍNDOLA, Otavio Melo et al. Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development. International Journal of Infectious Diseases, p. 1-23, 2020.1201-9712https://arca.fiocruz.br/handle/icict/4431110.1016/j.ijid.2020.10.044Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Laboratório Neurolife. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Hospital Federal dos Servidores do Estado. Departamento de Doenças Infecto Parasitárias. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Neuroinfecções. Rio de Janeiro, RJ, Brasil / Complexo Hospitalar de Niterói. Serviço de Neurologia. Niterói, RJ, Brasil.Objectives: To analyze the cerebrospinal fluid (CSF) of patients with SARS-CoV-2 infection and neurological manifestations to provide evidence for the understanding of mechanisms associated with central nervous system (CNS) involvement in COVID-19. Methods: Patients (n=58) were grouped according to their main neurological presentation: headache (n=14); encephalopathy (n=24); inflammatory neurological diseases, including meningoencephalitis (n=4), acute myelitis (n=3), meningitis (n=2), acute disseminated encephalomyelitis (ADEM) (n=2), encephalitis (n=2), and neuromyelitis optica (n=1); and Guillain-Barré syndrome (n=6). Data about age, sex, cerebrovascular disease, and intracranial pressure were evaluated in combination with CSF profiles defined by cell counts, total protein and glucose levels, concentration of total Tau and neurofilament light chain (NfL) proteins, oligoclonal band patterns, and detection of SARS-CoV-2 RNA. Results: CSF of patients with inflammatory neurological diseases was characterized by pleocytosis and elevated total protein and NfL levels. Patients with encephalopathy were mostly older men (mean age of 61.0 ± 17.6 years) with evidence of cerebrovascular disease. SARS-CoV-2 RNA in CSF was detected in 2 of 58 cases: a patient with refractory headache, and another who developed ADEM four days after COVID-19 symptoms onset. Three patients presented intrathecal IgG synthesis, and four had identical oligoclonal bands in CSF and serum, indicating systemic inflammation. Conclusion: Patients with neurological manifestations associated with COVID-19 had diverse CSF profiles, even within the same clinical condition. Our findings indicate a possible contribution of viral replication on triggering CNS infiltration by immune cells and the inflammation promoting neuronal injury.engElsevierhttps://www.arca.fiocruz.br/handle/icict/51150Cerebrospinal fluid findings in neurological diseases associated with COVID-19 and insights into mechanisms of disease development (preprint)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19SARS-CoV-2Cerebrospinal fluidNeurofilament light proteinTotal Tau proteinOligoclonal bandsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZEspíndola, Otávio MeloBrandão, Carlos OtávioGomes, Yago Côrtes PinheiroSiqueira, Marilda Agudo Mendonça Teixeira deSoares, Cristiane NascimentoLima, Marco Antônio Sales DantasLeite, Ana Claudia Celestino BezerraTorezani, GuilhermeAraujo, Abelardo Queiroz CamposSilva, Marcus Tulius TeixeiraLICENSElicense.txtlicense.txttext/plain; charset=utf-83134https://arca.fiocruz.br/bitstreams/3ee106fc-2a47-4b21-a823-518e8bc8902b/download0ab46789d568c4ba27c7b5d29a9fe9c4MD51falseAnonymousREADORIGINALEspíndola_Otavio_etal_INI_IOC_2020_COVID-19_PREPRINT.pdfEspíndola_Otavio_etal_INI_IOC_2020_COVID-19_PREPRINT.pdfapplication/pdf2562149https://arca.fiocruz.br/bitstreams/39d13958-3a9c-4d09-ab9c-71fbb038462f/download34c5b438bc36240c6a052a05f94836c2MD52trueAnonymousREADTEXTEspíndola_Otavio_etal_INI_IOC_2020_COVID-19_PREPRINT.pdf.txtEspíndola_Otavio_etal_INI_IOC_2020_COVID-19_PREPRINT.pdf.txtExtracted texttext/plain47545https://arca.fiocruz.br/bitstreams/25854b6b-347c-4a7c-b34a-45ddfbd14191/downloade4dca3a1aa11ef9ed4b91e6d1fbfa365MD513falseAnonymousREADTHUMBNAILEspíndola_Otavio_etal_INI_IOC_2020_COVID-19_PREPRINT.pdf.jpgEspíndola_Otavio_etal_INI_IOC_2020_COVID-19_PREPRINT.pdf.jpgGenerated Thumbnailimage/jpeg26192https://arca.fiocruz.br/bitstreams/03249abb-1c4b-4f28-9e8b-0dbb9b5e7f27/download20f38874271d0b46f91170c1ca3b5d31MD514falseAnonymousREADicict/443112025-12-11 08:31:55.814open.accessoai:arca.fiocruz.br:icict/44311https://arca.fiocruz.brRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352025-12-11T11:31:55Repositório Institucional da FIOCRUZ (ARCA) - 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