Cerebrospinal fluid biomarkers of neurodegeneration, synaptic integrity, and astroglial activation across the clinical Alzheimer's disease spectrum

Introduction: We investigated relations between amyloid-beta (A beta) status, apolipoprotein E (APOE) e4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). Methods: We included 770 individuals with normal cognition, mild co...

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Detalles Bibliográficos
Autores: Bos, I, Vos, S, Verhey, F, Scheltens, P, Teunissen, C, Engelborghs, S, Sleegers, K, Frisoni, G, Blin, O, Richardson, JC, Bordet, R, Tsolaki, M, Popp, J, Peyratout, G, Martinez-Lage, P, Tainta, M, Lleo, A, Johannsen, P, Freund-Levi, Y, Frolich, L, Vandenberghe, R, Westwood, S, Dobricic, V, Barkhof, F, Legido-Quigley, C, Bertram, L, Lovestone, S, Streffer, J, Andreasson, U, Blennow, K, Zetterberg, H, Visser, PJ
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p2715
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=2715
https://cris.maastrichtuniversity.nl/en/publications/cerebrospinal-fluid-biomarkers-of-neurodegeneration-synaptic-inte
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Amyloid-beta
Neurofilament light
Neurogranin
YKL-40
Cognition
Cerebrospinal fluid
APOE
Descripción
Sumario:Introduction: We investigated relations between amyloid-beta (A beta) status, apolipoprotein E (APOE) e4, and cognition, with cerebrospinal fluid markers of neurogranin (Ng), neurofilament light (NFL), YKL-40, and total tau (T-tau). Methods: We included 770 individuals with normal cognition, mild cognitive impairment, and Alzheimer's disease (AD)-type dementia from the EMIF-AD Multimodal Biomarker Discovery study. We tested the association of Ng, NFL, YKL-40, and T-tau with A beta status (Ab beta- vs. A beta+), clinical diagnosis APOE epsilon 4 carriership, baseline cognition, and change in cognition. Results: Ng and T-tau distinguished between A beta+ from A beta- individuals in each clinical group, whereas NFL and YKL-40 were associated with A beta+ in nondemented individuals only. APOE epsilon 4 carriership did not influence NFL, Ng, and YKL-40 in A beta+ individuals. NFL was the best predictor of cognitive decline in A beta+ individuals across the cognitive spectrum. Discussion: Axonal degeneration, synaptic dysfunction, astroglial activation, and altered tau metabolism are involved already in preclinical AD. NFL may be a useful prognostic marker. (C) 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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