Easy access to evans’ oxazolidinones. Stereoselective synthesis and antibacterial activity of a new 2-oxazolidinone derivative
An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct....
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2014 |
| País: | Brasil |
| Institución: | Universidade Federal de Viçosa (UFV) |
| Repositorio: | LOCUS Repositório Institucional da UFV |
| Idioma: | inglés |
| OAI Identifier: | oai:locus.ufv.br:123456789/12568 |
| Acceso en línea: | http://dx.doi.org/10.3390/molecules19067429 http://www.locus.ufv.br/handle/123456789/12568 |
| Access Level: | acceso abierto |
| Palabra clave: | Evans’ oxazolidinones Stereoselective synthesis Morita-baylis-hillman adduct Staphylococcus aureus Mastitis bovina |
| Sumario: | An interesting new approach was developed for the synthesis of Evans’ chiral auxiliaries with excellent yields. In turn, another new stereoselective and efficient strategy has also allowed for the preparation of a 2-oxazolidinone derivative in 34% overall yield from the Morita-Baylis-Hillman adduct. The antibacterial activity of this oxazolidinone was tested against Staphylococcus aureus strains isolated from animals with mastitis infections. |
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